AAMRA Allied Ayurveda Medical Research Abstracts

Abstract no :  2-1&2-DG-066 Author(s) :  Ohba, H.; Toyokawa, T.; Yasuda, S.; Hoshino, T.; Itoh, K.; Yamasaki, N. Address :  Kyushu National Industrial Research Institute, Shuku-Machi, Tosu, Saga 841, Japan Source :  Bioscience, Biotechnology and Biochemistry,v. 61(4): p. 737-739, 1997. Title :  SPECTROSCOPIC ANALYSIS OF THE CYTOAGGLUTINATING ACTIVITY OF ABRIN-B ISOLATED FROM ABRUS PRECATORIOUS SEEDS AGAINST LEUKEMIC CELL. Abstract :      The cytoagglutinating activity of abrin-b, a toxic lectin isolated from Abrus Precatorius seeds, (Gunja) against cultured cell strains derived from  accute lymphoblast leukemia was investigated by visible spectroscopy.  Upon addition of abrin-b, the turbidity at 600nm of cell suspension decreased and this change could be recorded as the cytoagglutination curve.  Fromthis curve, the cytoagglutination velocity (CV) cytoagglutination intensity (CI) of each cell strain was measured.  Each cell strain showed the respective CV and CI values and the

Abstract no :  2-1&2-DG-065 Author(s) :  Farook, T.; Vanithakumari, G. *; Bhuvaneswari, G.; Malini, T. Address :  Department of Endocrinology, Post Graduate Institute of Basic Medical Sciences, Taramin, Madras 600 113, TN, India Source :  Journal of Research in Ayurveda and Siddha, v. 15(3-4): p. 167-170, 1994 Title :  EFFECT OF ANETHOLE ON ACCESSARY SEX TISSUE OF ALBINO RATS. Abstract :      Anethole, a major constituent of the Foeniculum vulgare (Misreya) was administered  at two doses, i.e., 10 mg.(low) and 50 mg. (high)/100 g. body weight intramuscularly for 7 days.  While both doses caused a significant decrease in dorsolateral prostate weight, high dose alone was effective in reducing the coagulating gland weight.  Fructose concentrations were significantly decreased in both tissues after both low and high dose anethole treatment.

Abstract no :  2-1&2-DG-064 Author(s) :  Kavimani, S.; Ilango, R.; Thangadurai, J.G.; Jaykar, B.; Majumdar, U.K.; Gupta, M. Address :  Department of Pharmacology, Periyar College of Pharmaceutical Sciences for Girls, Trichy, Tamil Nadu 620021, TN, India Source :  Indian Journal of Pharmaceutical Sciences, v. 59(2): p. 96-98, 1997. Title :  DIURETIC ACTIVITY OF AQUEOUS EXTRACT OF ORTHOSIPHON THYMIFLORUS IN RATS. Abstract :      Efficacy of aqueous extract of Orthosiphon thymiflorus (Arjaka) tested for diuretic activity in rats has been discussed.  The extract given orally did not act as an aquaretic.  The values of urine volume were only slightly elevated.  The ion excretion was considerably increased.

Abstract no :  2-1&2-DG-063 Author(s) :  Nada, S.A.; Bashandy, S.A.E.; Negm, S.A. Address :  Department of Pharmacology, National Research Centre, El-Tahrir St. Dolli, Cairo, Egypt Source :  Fitoterapia, v.68(3): p. 240-244, 1997. Title :  EVALUATION OF THE HYPOGLYCEMIC ACTIVITY OF A TRADITIONAL HERBAL PREPARATION IN MALE DIABETIC RATS. Abstract :      The hypoglycaemic activity of a daily oral dose (1 g/kg) of a 10 percent decoction of an Egyptian widely used folk antidiabetic herbal preparation (PSP) and glibenclamide (Glib) were studied in alloxanized male rats for eight weeks.  PSP is a mixture of equal portions of the powdered seeds of Aloe vera, (KUMARI) Lupinus termis, Trigonella foenum-graecum, (METHIKA) Commiphora myrrha, (Bola) Broania critica and Rheum officinale (Vriksamla). PSP decreased the serum glucose level gradually while Glib exhibited a sharp fall of serum glucose level after 2,4 and 8 weeks of treatment fo diabetic male rats.  PSP inudced a significant de

Abstract no :  2-1&2-DG-062 Author(s) :  Chiu, K.W.; Fung, A.Y.L. Address :  Department of Biology, The Chinese University of Hong kong, Hong kong, China Source :   Phytotherapy Research, v. 11(3): p. 203-206, 1997. Title :  THE HYPOTENSIVE EFFECTS OF GREEN BEAN (PHASEOLUS AUREUS), COMMON RUE (RUTA GRAVEOLENS) AND KELP (LAMINARJA JAPONICA) IN RATS. Abstract :      Aqueous extracts of green bean (Kalaya) common rue (Sadapa) and kelp were found to be hypotensive, contained bioactive proteinaceous substanes and stimulated urine flow.  A combination of two of three plant extracts showed subtractive or additive effects, suggesting important bearing on their use  therapeutically.

Abstract no :  2-1&2-DG-061 Author(s) :  Nair, R.B.; Pillai, R.P.; Pillai, B.K.R; Vijayaraj, S.; Nair, C.P.R. Address :  Regional Research Institute D.R, Trivandrum 695 012, Kerala, India Source :  Journal of Research in Ayurveda and Siddha,  v. 15(3-4): p. 155-166, 1994. Title :  HYPOCHOLESTEROLAEMIC ACTION OF THREE GUGGULU (COMMIPHORA MUKUL) PREPARATIONS - A COMPARATIVE STUDY. Abstract :      A comparative study of the hypocholesterolaemic effect of three guggulu preparations, viz.  Kaisora guggulu, Yogaraja guggulu and Navaka guggulu on albino rats is given.  The minimum effective dose of the guggulu preparations is 1 g/kg.b.w. of rats bringing about significant reduction in serum and liver cholesterol levels.  Among the three preparations,  Kaisora guggulu seems to have greater hypocholesterolaemic and antiobese action compared with the other two drug preparations.

Abstract no :  2-1&2-DG-060 Author(s) :  Padma P.; Chansouria J.P.N.; Khosa, R.L. Address :  Department of Pharmaceutics, Banaras Hindu University, Varanasi 221 005, UP, India Source :   Phytocherapy Research, v. 11(4): p. 326-327, 1997. Title :  EFFECT OF ALCOHOL EXTRACT OF ANNONA MURICATA ON COLD IMMOBILIZATION STRESS INDUCED TISSUE LIPID PEROXIDATION. Abstract :      Administration of an ethanol extract of the stem bark of Annona muricata (Ramaphal) significantly inhibited cold immobilization in stress-induced lipid peroxidation in the liver and brain of albino rats.

Abstract no :  2-1&2-DG-059 Author(s) :  Prassannakumar. G; Sudheesh. S; Ushakumari. B; Valsa.A. K; Address :   Vijaykumar.C; Sandya & Vijayalaxmi.N.R. Department  of  Biochemistry, University of  Kerala,  Karivettam, Thiruvanathapuram - 695581, India. Source :  Journal of Food Scienca and Technology, 1997, Vol.34, No.2,  103-107 Title :  A COMPARATIVE STUDY ON THE HYPOLIPIDEMIC ACTIVITY OF ELLEVEN DIFFERENT PECTINS Abstract :      Inclusion  of  pectin-rich  fruits  and  vegetables  can  be regarded   as  one  of  the  primary  prevention  strategies   of hyperlipidemia.  But, it has been found that all pectins  do  not show  effective  hypolipidemic  activity.  Eleven  pectins   were screened  among which pectins from Carica papaya, (ERANDA KARKATI) Coccinia indica (Bimbi), Lycopersicum esculentum (Tamatur)  and cumns sativus (Trapusa) showed highly significant  hypolipidemic activity in albino rats, while  others were less significant or insignificant in their action.

Abstract no :  2-1&2-DG-058 Author(s) :  Tripathi.Y.B, Mukta Sharma, Manickam.M., Address :   Department  of  Medicinal Chaemistry, Institute of  Medical  Sciences, Banarus Hindu University, Varanasi - 221005, India., Source :   Indian journal of Biochemistry and Biophysics, Vol.34,June  1997, pp. 302-306. Title :  RUBIADIN, A NEW ANTIOXIDANT FROM RUBIA CORDIFOLIA Abstract :      Rubiadin a dihydroxy anthraquinone, isolated from  alcoholic extract   of  Rubia  cordifolia, (MANJISHTA)  possesses  potent   antioxident property.  It prevents lipid perioxidation induced by FeSO4,  and t-butyl  hydroxide  (t-BHP) in a  dose  dependent  manner.  The percent  inhibition  was more in the case of Fe2+  induced  lipid perioxidation.  The antioxident property of the  preparation  has been  found  to  be better than that  of  EDTA,  Tris,  mannitol, Vitamin E and p-benzoquinone.

Abstract no :  2-1&2-DG-057 Author(s) :  Singh.R.K, Gopalnath. Acharya.S.B & Goel.R.K Address :  Department  of Pharmacology & Microbiology, Institute of  Medical Sciences, Banaras hindu University, Varanasi - 221005, India., Source :   Indian  Journal of Experimental   Biology,Vol.35,August 1997,pp.831-836. Title :  PHARMACOLOGICAL ACTIONS OF PONGAMIA PINNATA ROOTS IN ALBINO RATS Abstract :      Pongamia  pinnata (Karanja)  root  has  been  advocated  in  Ayurveda   for treatment   of  various  inflamatory  and  infective   conditions including ulcers. Sequential petroleum  ether, benzene,chloroform,acetone  and ethanolic extracts  of  P.pinnata root  when  adminstered in the dose of 50 mg/kg. p in  rats  was found   to  have  anti-inflamatory,  analgesic   activity   while pentabarbitone  induced  ‘sleep  time’ was reduced  by  all  the extracts except petroleum ether which, however, enhanced it. They were  also found to posses anti-ulcer effects  when  administered

Abstract no :  2-1&2-DG-056 Author(s) :  Ahmed.R.S & Sharma .S.B, Address :  Biochemistry Department, Universsity College of Medical  sciences and GTR hospital, Delhi - 110095, India., Source :  Indian  journal of Experimental Biology, Vol.35,August  1997,  pp 894-897 Title :  BIOCHEMICAL  STUDIES ON COMBINED EFFECTS OF  GARLIC  [ALLIUM  SATIVUM  LINN]  AND GINGER [ZINGIBER OFFICINALE ROSE]  IN  ALBINO RATS Abstract :      Adult  male  rats of wistar strain were fed  diets  containg (w/w)  2%  garlic  (group  2),  0.5%  ginger  (group  3)  and a combination of garlic(LASUNA) plus ginger (ARDRAKA) (group 4) for  4  weeks  to  study  their  effects  on  serum   biochemical parameters. A significant increase in body weight was observed in all groups except that fed ginger (gr.3). A significant  decrease in  blood  glucose,  serum total cholestrol  and  serum  alkaline phosphatase   were   found  in all groups, where as serum triglyserides were decreased significantly only in

Abstract no :  2-1&2-DG-055 Author(s) :  Z.S.Hakim, R.A.Bangaru, D.D.Santani and R.K.Goyal, Address :   Department of Pharmacology, L.M.College of Pharmacy, Ahmedabad - 380 009, Source :  India J. Nat. Prod., 11 (1),3 Title :  POTENTIAL ANTIDIABETIC AGENTS FROM PLANT SOURCES : PHARMACOLOGICAL ASPECTS Abstract :      Diabetes mellitus is a common chronic endocrine disorder. Since ancient times a number of herbal medicines have been used in the treatment of this disease. Many studies have been carried out in the search of suitable plant drug that would be effective in Diabetes mellitus. The pharmacological actions of active principles obtained from various plants have been studied in India and abroad. This article reviews some of the  better planned studies, which include herbs like, Karavellaka; Palandu; Bijaka; Vata; Agnimantha; Chandra prabhavati; Kumari; SUNTI; Parusaka; Parpataka; . Amlaki; Methika & Rakta chandana etc.

Abstract no :  2-1&2-DG-054 Author(s) :  Sunita Teotia, Man Singh and Pant.M.C Address :  Centre  for  Biomedica  Engineering,  Indian  INstitute   of Technology, New Delhi - 110016, India, Source :  Indian  Journal of Physiology and Pharmacology  1997;  41(4); pp. 383-389. Title :  EFFECT OF PRUNUS AMYGDALUS SEEDS ON LIPID PROFILE Abstract :      The effect of Prunus amygdalus, (Vatada)  which is rich in unsaturated fat,   fibre   diet  and  low  cholestrol  was  studied   in   36 normolipidemic  male albino rabbits for 60 days.  Three  different doses  i.e.  whole seeds defattted and oil showed a  decrease  in serum  total cholestrol, triglycerides, LDL ans  HDL  cholestrol. The maximum effects were shown by whole seeds followed by oil and defatted.

Abstract no :  2-1&2-DG-053 Author(s) :  Rajender Singh, Singhal.K.C. & Nizam U. Khan Address :  Department of Pharmacology, J.N. Medical College,  Aligarh  - 202002  &  Department of  Chemistry,  Aligarh  Muslim  University, Aligarh - 202002, India, Source :  Indian Journal of Physiology and Pharmacology 1997; 41(40  : pp.397-403. Title :  ANTIFILARIAL  ACTIVITY OF MALLOTUS PHILLIPPINENSIS  LAM.  ON SETARIA CERVIE (NEMATODA: FILAROIDEA) IN VITRO Abstract :      The effect of aqueous and alcoholicc extracts of the  leaves of Mallotus philippinensis (Lam.) Muell. Arg. (Kampillaka)  was studied on  the spontaneous  movements of the whole worm and nerve-muscle  (n.m.) preparation of Setaria cervi and the survival of microfilariae in vitro.  Both  the  extracts  caused  inhibition  of   spontaneous motility  of  whole  worm and the n.m. preparation of S.cervi charecterised by intial stimulation followed by  depression of amplitude.  The  tone and rate of contractions rema

Abstract no :  2-1&2-DG-052 Author(s) :  Sunand Panda and Anand Kar, Address :  School  of  Life Sciences, D.A. University,  Vigyan  Bhavan, Khandwa Road, Indore - 452001, India, Source :  IndianJournalof Physiology and Pharmacology 1997; 41(4): pp. 424-426. Title :  EVIDENCE FOR FREE RADICAL SCAVENGING ACTIVITY OF ASHWAGANDHA ROOT POWDER IN MICE Abstract :      The  effects  of ASVAGANDHA root powder (0.7 and  1.4  g/kg b.w./day)  administered for 15 days and 30 days was  investigated on  lipid  perioxidation (LPO), superoxide  dismutase  (SOD)  and catalase  (CAT) activities in mice. While 15 days treatment  with ASVAGANDHA  root powder did not produce any significant  change, 30  days treatment produced a significant decrase in LPO, and  an increasa  in  both  SOD  and CAT.  Our  findingas  indicate  that ASVAGANDHA   root  powder  possesses  free  radical   scavenging activity,  which  may  be  responsible  for  its  pharmacological effects.

Abstract no :  2-1&2-DG-051 Author(s) :  Jayasekhar.P, Mohanan.P.V, Rathinam.K., Address :   Priyadasini Institute  of  Paramedical Sciences, Medical College,  Thiruvanathapuram  -  695011  &  Sree  Chitra   Tirunal Institute   for  Medical  sciences  and  Technology, Biomedical Technology  Wing, Poojapura, Thiruvanathapuram - 695012,  Kerala, India., Source :  Indian Journal of Pharmacology 1997; 29: pp 426-428. Title :  HEPATO PROTECTIVE ACTIVITY OF ETHYL ACETATE EXTRACT OF  ACACIA CATECHU Abstract :      Hepatoprotective activity of ethyl acetate extract of Acacia catechu (Khadira)  (katha)  is  studied in rats. The  accute  liver  damage in albino rats is induced by a single subcutanious administration of 4 ml/kg dose of 50% v/v carbon tetrachloride in olive oil  and the chronic liver damage by 2 ml/kg twice a week for 14 days. The hapatoprotective   activity   was  monitered   biochemically   by estimating serum transminase, serum alkaline phosphstase and seum biliru

Abstract no :  2-1&2-DG-050 Author(s) :  Vobalaboina Venkateshwarlu, Address :  University College of Pharmaceutical Sciences, Kakatiya University, Warangal - 506 009, A.P., India, Source :  Indian Drugs 34(8) August, 1997. Title :  CYCLO-OXYGENASE INHIBITORS FROM SPICES Abstract :      The crude extracts of fresh rhizomes of Zingiber officinale (ginger) (ARDRAKA), dried rhizomes of Curcuma longa (turmeric) ()  and dry fruits of Piper nigrum (black pepeer) (MARICAM), showed potent inhibitory activity against prostaglandin biosynthesizing enzyme (cyclo-oxygenase, PG synthetase) in an in vitro bioassay test. The extracts were fractionated by monitoring the activity to yield [10]-gingerol 1, [6]-gingerol 2 from ginger, 1,7-bis (4-hydroxy-3-methoxyphenyl) 1,6-heptadiene- 3,5-dione (curcumin) 3, phydroxycinnamoylferuloylmethane-1, 6-heptadiene- 3,5-dione 4 from turmeric and piperine 5 from black pepeer. Compounds 1-5 were characterized on the basis of their IR, NMR spectroscopic d

Abstract no :  2-1&2-DG-049 Author(s) :  Tandan S.K., Chandra S., Gupta S. & Lal J., Address :   Divn. of Pharmacology & Toxicology, Indian Votorinary  Research Instituto, Izatnaga 243 122 UP, Source :  Indian Journal of Pharmaceutical Sciences  PP 20- 23 Title :  PHARMACODYNAMIC EFFECTS OF CEDRUS DEODARA WOOD ESSENTIAL OIL Abstract :      The Pharmacodynamic effects of Cedrus deodara (Devadaru)  wood essential oil were investigated in mice and rats. The oil was found to possess significant anti-inflammatory activity in carrageenin-induced oedema in rats.  If was devoid of analgesic, sedative and motor incoordinating activities in mice.  However, it caused  a significant increase in pentobarbitone-induced hypnosis which may be due to inhibition of drug metabolising enzymes.

Abstract no :  2-1&2-DG-048 Author(s) :  H.K. Singh, B.N. Dhawan, Address :  Central Drug Research Institute, Lucknow - 226 001. India, Source :  Indian Journal of Pharmacology 1997; 29: S359-S365 Title :  NEUROPSYCHOPHARMACOLOGICAL EFFECTS OF THE AYURVEDIC NOOTROPIC BACOPA MONNIERA LINN. (BRAHMI) Abstract :      Bacopa monniera Linn. (BRAHMI) has been used since times immemorial as nerve for improvement of memory. The authentication of the traditional claims of BRAHMI was initiated by investigating the effect of an alcoholic extract of this plant on acquisition, consolidation and retention of three newly acquired behavioural responses in albino rats, viz., a foot-shock motivated brightness discrimination response, active conditioned avoidance response and Sidman continuous avoidance response. The facilitator effect of the BRAHMI extract (40 mg/kg. p.o x 3d) was manifest in all the three learning responses as it augmented both the cognitive function and mental retention capac

Abstract no :  2-1&2-DG-047 Author(s) :  Rao, K.S.; & Mishra, S.H.*, Address :   Pharmacy Department faculty of Technology & Engineering, M.S. University of Baroda Vadodara- 390 001, Gujarat, Source :  Indian J. Pharm. Sci., 1998, 60(1) pp. 12-16 Title :  ANTI-INFLAMMATORY AND ANTIHEPATOTOXIC ACTIVITIES OF THE ROOTS OF MORINGA PTERYGOSPERMA GAERTN Abstract :      The roots of Moringa pterygosperma Gaertn (SIGRU). (Moringaceae) in powder and extract form were studied for their anti-inflammatory and antihepatotoxic activities.  Among these, the methanolic extract showed significant (p<0.01) oedema suppressant activity against carrageenin induced paw oedema similar to that of indomethacin.  The aqueous extract against carbon tetrachioride, total aqueous extract against paracetamol and methanolic extract against rifampicin treatments showed significant (p<0.01) antihepatotoxic activity.

Abstract no :  2-1&2-DG-046 Author(s) :  Souza R.D.; Singh, U.V.; Aithal, K.S. & Udupa, M.* Address :   Department of pharmaceutics, College of Pharmaceutical Sciences, Manipal 576 119, Karnataka, Source :  Indian J. Pharm. Sci., 1998, 60(1) pp. 36-40 Title :  ANTIFERTILITY ACTIVITY OF NIOSOMAL HPßCD-PLUMBAGIN COMPLEX Abstract :      Inclusion complex of drug with hydroxyl propyl  betacyciodextrin (HPßCD) was prepared with a view  to increase the efficacy and soiubility of plumbagin the active constituent of Plumbago zeylanicum (CHITRAKA).  The complex was entrapped in the aqueous layer of niosomes and evaluated for antifertility activity.  This in turn was compared with niosomes of the plain drug where entrapment was possible in the lipid layer.  Given Intraperitoneally at a dose of 5 mg/kg the niosomes of the drug complex showed promising antifertility activity when compared to the control and niosomes with lipid layer  entrapment.  Although complex showed lower entrapm

Abstract no :  2-1&2-DG-045 Author(s) :  Ruckmani, K.; Kavimani, S.; Anandan, R. & Jayakar, B. Address :  Periyar College of Pharmaceutical Sciences for girls, Trichy 21., Source :  Indian J. Pharm. Sci., 1998, 60(1) pp. 33-35 Title :  EFFECT OF MORINGA OLEIFERA LAM ON PARACETAMOL-INDUCED HEPATOTOXICITY Abstract :      Aqueous and alcoholic extracts of root and flower of M. oleifera (SIGRU) were screened for antihepatotoxic activity in paracetamol treated albino rats.  Liver function was assessed based on liver to body weight ratio, serum levels of transaminase (SGPT, SGOT), alkaline phosphatese (SALP) and bilirubin.  All extracts were found to have antihepatotoxic activity.

Abstract no :  2-1&2-DG-044 Author(s) :  Annu Khajuria, Usha Zutshi & Bedi, KL Address :  Isotope Section,  Regional Research Laboratory, Canal Road, Jammu-Tawi, India, Source :  Indian Journal of experimental Biology Vol. 36, January 1998, pp.46-50 Title :  PERMEABILITY CHARACTERISTICS OF PIPERINE ON ORAL ABSORPTION-AN ACTIVE ALKALOID FROM PEPPERS AND A BIOAVAILABILITY ENHANCER Abstract :      Piperine, (1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4, pentadieny1) piperidine), is  a pungent alkaloid present in Piper nigrum (MARICAM)  and P.longum (PIPPALI) Linn.  It is shown to enhance the bioavailability of various structurally and therapeutically diverse drugs.  A concise mechanism responsible for its bioavailability enhancing action is poorly understood.  This study is an effort to understand the absorption dynamics of piperine in intestine on oral absorption.  It encompasses intestinal everted sacs as an experimental model.  Cycloheximide treatment and exclusion of Na+ salts

Abstract no :  2-1&2-DG-043 Author(s) :  Rajesree, C.R. & Rajamohan, T.; K.T. Augusti, Address :  Department of Biochemistry, Univeristy of Kerala, Thiruvenanthapuram 695 581, India, and School of Medical Education, M.G. University Centre, Medical College Campus, Kottayam 686 008, India, Source :  Indian Journal of Experimental Biology Vo. 36, January 1998, pp. 60-64 Title :  ANTIPEROXIDE EFFECT OF GARLIC PROTEIN  IN ALCOHOL FED RATS Abstract :      Rats fed ethanol (3.76g/Kg body wt/day) for about 45 days exhibited high levels of tissue malondialdehyde, hydroperoxide and diene conjugates.  Activity of tissue superoxide dismutase, catalase, and glutathione content decreased.  Administration of water soluble proteins of garlic (LASUNA) (500mg/kg body wt/day) to alcohol fed rats showed significant increase in antiperoxide activity and decrease in the activity of glutathione peroxidase and glutathione transferase as compared to a standard drug gugulipid (50 mg/kg body wt/day

Abstract no :  2-1&2-DG-042 Author(s) :  Srivastava KC. Address :  Department of Environmental Medicine, Odense University, Denmark, Source :   Prostaglandins Leukotrienes & Essential Fatty Acids. 37(1) : 57-64, 1989 Jul. Title :  EXTRACTS FROM TWO FREQUENTLY CONSUMED SPICES—CUMIN (CUMINUM CYMINUM) AND TURMERIC (CURCUMA LONGA)— INHIBIT  PLATELET AGGREGATION AND ALTER EICOSANOID BIOSYNTHESIS IN HUMAN BLOOD PLATELETS. Abstract :      In the traditional Indian system of medicine, Ayurveda, several spices and herbs are claimed to possess medicinal properties, such as being antithrombotic, antiatherosclerotic, hypolipidemic, anti-inflammatory etc.  Earlier we have reported  that extracts from several spices behave as antiaggregatory agents and inhibit eicosanoid synthesis.  Similar studies with extracts prepared from cumin (Cuminum cymimum) (Jiraka) and turmeric (Curcuma longa) (HARIDRA) were undertaken.  Ethereal extract of both cumin and turmeric inhinited arachidonate-induc

Abstract no :  2-1&2-DG-041 Author(s) :  Rajendran V, Joseph T, David J., Address :  Department of Pharmacology, St. Joh’s Medical College, Bangalore -560034, Source :  Indian Drugs 1997, 43(3), 136-9. Title :  MUCUNA PRURIENS DECREASES SEXUAL ACTIVITY IN FEMALE RATS. Abstract :      Mucuna pruriens (MP) (Kapikcchu) seed powder 3g. containing 100 mg L-dopa (LD) showed a more significant inhibitory effect than 100 mg LD on sexual behaviour in sexually receptive female rats.  The females showed rejection and exhibited decreased lordosis when males attempted to mount. The index of rejections indicated as a significant decrease in lordosis quotient with a corresponding increase in rejection quoteint.  The same animals on treatment with water a week earlier or later accepted the male without any rejection.  The results indicate that while both LD & MP inhibited sexual behaviour in females, the inhibitory effect of MP was more than that of LD indicating the presence of other co

Abstract no :  2-1&2-DG-040 Author(s) :  Sharma, S.S; & Gupta, Y.K. Address :  Department of Pharmacology, All India Institute of Medical Sciences, New Delhi - 110 029, Source :  Ind. Journal of Pharmacology v 29/1 feb 1997. Title :  EFFECT OF GINGER ON CISPLATIN INDUCED DELAY IN GASTRIC EMPTYING IN RATS Abstract :      Cisplatin causes nausea, vomiting and slowing in gastric emptying.  We have demonstrated antiemetic effect of ginger acetone and ethanolic extracts against cislatin induced emesis in dogs.  In the present study effect of ginger (ARDRAKA) extracts and ginger juice was investigated in cisplatin induced delay in gastric emptying.  Wistar rats of either sex Weighing 150-200 g were used.  The animals were deprived of food 24 hr prior to the experiment.  Cisplatin 10 mg/kg, i.p. was administreted 30 min before the test meal.  After 30 min of test meal administration, rats were sacrificed for determination of percent gastric emptying.  Acetone and alcoholic extra

Abstract no :  2-1&2-DG-039 Author(s) :  Rastogi, R. & Dhawan, B.N. Address :  ICMR Centre for advanced Pharmacological Research on Traditional remedies, Biochemistry Division, Central Drug Research Institute, Lucknow - 226 001 Source :  Ind. Journal of Pharmacology v 29/1 feb 1997. Title :  EFFECT OF PICROLIV ON IMPAIRED DRUG METABOLISM IN CARBON TETRACHLORIDE TOXICATED RATS Abstract :      Carbon tetrachloride (CCI4) induced hepatotoxicity is a commonly used model for investigating  lipid-peroxidation related tissue injury.  In the present study, a drastic impairment in hepatic drug metabolism was observed in rats 24 hr following administration of CCI4 (1.0 ml/kg, i.p., single) as indicated by decrease in the activities of various microsomal drug metabolising components viz., aminopyrine-N-demethylase, aniline hydroxylase, NADH-cytochrome C-reductase, NADPH-cytochrome C-reductase, cytochrome P450 and glutathione-S-transferase.  Picroliv (an iridoid glycoside fraction ob

Abstract no :  2-1&2-DG-038 Author(s) :  Visen, P.K.S; Saraswati, B; Patnaik, G.K. & Dhawan, B.N; Address :  ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Division of Pharmacology, Central Dkrug Research Institute, Lucknow, Source :  Ind. Journal of Pharmacology v 29/1 feb 1997. Title :  PROTECTIVE EFFECT OF PICROLIV AGAINST RIFAMPICIN INDUCED TOXICITY Abstract :      The antibiotic rifampicin is widely used in the treatment of tuberculosis and leprosy.  Prolonged use of rifampicin has been reported to cause hepatotoxicity.  Picroliv,  the active constituent of Picrorhizk kurroa (Katuki) has earlier been reported to possess potent hepatoprotective activity against rifampicin toxicity by reversing the changed biochemical parameters significantly.  The present study was aimed to see the effect of picroliv on additional selected parameters of rifampicin hepatotoxicity.  Administration of rifampicin (50 mg/kg, p.o. x 6) alone resulted in 26.32% re

Abstract no :  2-1&2-DG-037 Author(s) :  Vijayalakshmi, R; Y.H. Quadri, S.S. & Deosthale, G; Address :   Centre for Liver Disease, Owaisi Medical and Research Centre, Kanchanbagh, Hyderabad - 500 258, Source :  Ind. Journal of Pharmacology v 29/1 feb 1997. Title :  EFFECT OF EUGENOL ON GASTRIC FUNCTION IN RATS Abstract :      Eugenol, an active principle of clove, (Lavanga) is an effective secretagogue in rats, causing dose dependent augmentation of gastric secretion. Eugenol, when administered intragastrically at 100 µg/kg body weight, stimulated maximum secretion of gastric free acid and serum pepsinogen, However, at higher concentration it has an inhinitory effect on gastric secretion.  Long term oral treatment of ougenol at a dose of 100 µg/kg body weight per day for three weeks significantly increases the serum pepsinogen levels, which positively correalted with gastric free acid secretion,  The levels of serum mucoprotein and _-antitrypsin remained unchanged.  Histo

Abstract no :  2-1&2-DG-036 Author(s) :  Dhawan, B.N; Address :  Division of Pharmacology and Biochemistry, Central Drug Research Institute, Lucknow - 226 001 Source :  Ind. Journal of Pharmacology v 29/1 feb 1997. Title :  LIVER REGENERATION IN RATS AFTER PARTIAL HEPATECTOMY: INFLUENCE OF PICROLIV Abstract :      Regeneration of the liver after partial hepatectomy is one of the most popular and frequently used model for the study of cell grwoth and cell differentiation.  Two stages are important in the study of regeneration.  The initial stage, when the cell switch to the proliferating pool and the end stage when the cells return to quiescent Go-phase.  The initial stage is characterized by an increase in number of cell divisions and of all metabolic processes.  The last stage during which mitotic activity decreases to normal levels, has not been throughly investigated.  In the present study the drug metaboilizing  cornponents were estimated during the end stage of liver reg

Abstract no :  2-1&2-DG-035 Author(s) :  Khajurial, A; Shanna, M.L. & Sharma, O.P. Address :  Department of Pharmacology, Regional Research Laboratory, Jammu and Department of Biosciences, Jammu University, Jammu. Source :  Indian Journal of Pharmacology v 29/1 feb 1997. Title :  MODULATION OF SPECIFIC AND NON-SPECIFIC IMMUNE RESPONSE BY OCIMUM SANCTUM Abstract :      Ocimum sanctum (TULASI) a traditional medicinal plant helps to create conditions favourable for the host defence mainly through the augmentation of humoral as well as cell mediated immunity.  Besides these effects, O.sanctum (AEOS) strengthens the biological activities and is used as an adaptogen against stressed conditions.  The present study  was undertaken to evaluate the effect of  O.sanctum on immune system. It was observed that oral administration  of aqueous extract of O.sanctum enhanced the antibody production in stressed rats, when compared to control.  Immunological defects which are connected with

Abstract no :  2-1&2-DG-034 Author(s) :  Harinet Singh Rehana & Motapurkar, B.G.* Address :  Department of Pharmacology, PKIHS,  Dharan, Nepal and LNJP Hospital, New Delhi, Source :  Ind. Journal of Pharmacology v 29/1 feb 1997. Title :  PHARMACOLOGICAL PROFILE OF TENDER COCONUT WATER Abstract :      Coconut (Narikela) water is cheap and easily available in coastal areas.  The high nutritive value and streile nature suggests its valuable therapeutic application.  Autocleving increases the shelf life with out affecting its nutritive value.  Intravenous administration of TCW (100 ml/kg) in dogs decreased serum Na+ levels and increased K+  and Ca 2+ levels.  ECG did not show any evidence of hyperkalemia.  It did not show effect on psychomotor and analgesic activity.  Repeated administration also did not reveal any allergy or anaphylaxis.  It is naturally available cost effective highly nourished fluid, ideal for parenteral substitute fluid.

Abstract no :  2-1&2-DG-033 Author(s) :  Kapur Ankur & Srinivasan, B.P Address :  .Department of Pharmacology, College of Pharmacy, New Delhi, Source :  Ind. Journal of Pharmacology v 29/1 feb 1997. Title :  ANTIHYPERGLYCAEMIC ACTIVITY OF NEEM LEAF EXTRACT IN STREPTOZOTOCIN INDUCED NONINSULIN DEPENDENT DIABETES MELLITUS Abstract :      The present study explores the effect of Neem (Nimba) Leaf Extract (NLE) in Non-Insulin dependent diabetes mellitus (NIDDM).  NIDDM was induced by interperitoneal injection streptozotocin (STZ) at a dose level of 90 mg/kg to 2 day old neonatal rats.  After 6 weeks of STZ injection, rats were grouped as non-diabetic, diabetic, neem leaf extract (1.g/Kg, p.o.), glibenclamide (0.025 mg/kg, p.o.) and metformin (200 mg/kg, p.o) treated groups.  The above treatment was continued for 6 weeks by daily oral dosing every morning.  Thereafter blood glucose estimation done by “glucose oxidase method”.  Both NLE and gliben clamide showed an `extremely s

Abstract no :  2-1&2-DG-032 Author(s) :  Ray, A; Banerji, B.D; Koner, B.C. & Sen, P. Address :  Department of Pharmacology and Biochemistry, U.C.M.S. and G.T.B. Hospital, Shahdara, Delhi - 110 095, Source :  Indian  Journal of Pharmacology v. 29/1 feb 1997 Title :  INFLUENCE OF AZADIRACHTA INDICA (NEEM) LEAF EXTRACT ON THE IMMUNOTOXICITY OF STRESS AND XENOBIOTICS IN EXPERIMETAL ANIMALS. Abstract :      A veriety of environmental stressors are known to influence immune function and the present study evaluated the effects of leaf extracts of Azadirachta indica (NIMBA) (Al, Neem) on the immunomodulation induced by restraint stress (RS) and the insecticide, DDT, in rats and mice, In rats immunized with sheep RBC (SRBC), RC (1h/dayx5) exposure suppressed the anti-SRBC antibody titres, and inhinited the increase in footpad thickness after SRBC challenge in mice.  Both these effects were attenuated after oral Al (100mg/kg, x5days) inhibited  the antibody response and suppressed

Abstract no :  2-1&2-DG-031 Author(s) :  Sarmistha Datta, Swati Sinha & Prantosh Bhattacharya, Address :  Department of Chemistry, Bose Institute, Calcutta-700 009 Source :  Ind. Journal of Pharmacology v 29/1 feb 1997. Title :  HEPATOPROTECTIVE EFFECT OF A PROTEIN DERIVED FROM CAJANUS INDICUS SPRENG ON CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN MICE Abstract :      Hepatotoxicity  by different chemicals is well known.  Liver has become the primary target as it is the major site for detoxification.  Treatment with carbon tetrachloride (CCI4) (0.1 ml/100 gms of body weight (b.wt); twice a week) induced acute hepatic necrosis in swiss albino mice (male; b.wt. 30 gms ± 2).  CCI4 induced hepatotoxicity and renal toxicity in albino mice caused significant alteration in the activities of glutamic oxaloacetic transaminase (GOT); glutamic Pyruvic transaminase (GPT); Alkaline and Acid phosphatase and serum bilirubin.  Administration of the protein fraction isolated from the le

Abstract no :  2-1&2-DG-030 Author(s) :  Saraswat, B; Visen, P.K.S; Patnaik, G.K. & Dhawan, B.N. Address :  ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Division of Pharmacology, Central Drug Research Institute, Lucknow, India Source :  Indian  Journal of Pharmacology v 29/1 feb 1997. Title :  PROTECTIVE EFFECT OF PICROLIV AGAINST ALCOHOL INDUCED HEPATOTXICITY IN RAT Abstract :      In order to develop herbal, hepatop protective agent for treatment  of alcohol induced liver disorders, protective activity of picroliv the active  constituent isolated form the plant Picrorhiza kurroa (KATUKI) was evaluated against ethanol induced hepatic injury.  Alcohol feeding (3.75 g/kg x 45 days) produced 25 to 90% alteration in selected biochemical serum (GOT. GPT and ALP) and liver markers (Lipid, glycogen and protein)  Further, it also resulted in 41 to 52% reduction in viability (as assessed by trypan blue exclusion and rate of O2 uptake) as well as in A

Abstract no :  2-1&2-DG-029 Author(s) :  Patel, B.G; Bhattz, M.I. & Dave, K.C. Address :  Department of Pharmacology, A.R. College of Pharmacy, Vallabh Vidyanagar-388 120.Torrent Pharmaceutical Pvt. Ltd., and Department of Pharmacology, Smt. N.H.L. Mun. Med. College and V.S. General Hospital, Ahmedabad - 380 006, Source :  Ind. Journal of Pharmacology v 29/1 feb 1997. Title :  CARDIOVASCULAR EFFECTS INDUCED BY VENOM OF SCORPION (BUTHUS TAMULUS) IN DOG Abstract :      The Cardiovascular effects of Lyophilized venom of Scorpion (Buthus tamulus) were investigated in anaesthetized dogs.  The Venom (0.1-0.25 mg/kg i.v.)  produced marked hypertensive effect with bradycardia.  Bradycardia caused by venom was prevented by atropine but not affected by hexamethonium or bilateral vagotomy.  The pressor response caused by venom was not affected by hexamethonium, abolished in reserpine treated dogs or by Phenoxybenzamine.  Higher dose of venom (0.5-1.5 mg/kg i.v.) caused cardiac arrhy

Abstract no :  2-1&2-DG-028 Author(s) :  Shukla, R; Prajapati, V; Anand, R; Patnaik, G.K. & Dhawan, B.N. Address :  ICMR Advanced Centre, Division of Pharmacology, Central Drug Research Institute, Lucknow Source :  Indian Journal of Pharmacology v 29 / 1 Feb. 1997 Title :  EFFECTIVE RAT MODEL FOR THE EVALUATION OF ADAPTOGENIC SUBSTANCES Abstract :      A modification cold-hypoxia-restraint rat model was developed for evaluating improvement in Physical work performance and endurance in adverse stressful environment, which is an essential characteristics  of an adaptogen endurance to a stressful condition.  A number of medicinal plants have been used in Indian system of Medicine as adaptogens, but  due to lack of scientific evaluation, both experimental and clinical, these drugs have not achieved due recognition.  In present investigation Asparagus racemosus (SATAVARI) root, Terminalia chebula (HARITAKI) and Emblica officinalis (AAMALAKI) fruits extracts and their fraction

Abstract no :  2-1&2-DG-027 Author(s) :  Chander Ramesh; Khanna, A.K. & Dhawan, B.N. Address :  Biochemistry Division and ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Research Institute, Lucknow- 226 001, Source :  Ind. Journal of Pharmacology v 29/1 feb 1997. Title :  PICROLIV  REGULATES LIPID METABOLISM IN PLASMODIUM BERGHEI INDUCED LIVER DAMAGE IN MASTOMYS CAUCHA Abstract :      Picroliv, the standardized preparation of iridoid glycosides; plcroside-1 and kutkoside, from Picrorhiza kurroa  (KATUKI) protects liver from damage caused by various hepatotoxins including hepatic damage following Plasmodium berghei (P. berghei) infection in Mastomys Caucha (M.Caucha).  The antioxidant effects and membrane stablishing action of picroliv are reported to contribute to its hepatoprotective activity.  Picroliv stimulates hepatic cholesterol-7A-hydroxylase and restores choleretic activity by increasing the biosynthesis and secretion of bil

Abstract no :  2-1&2-DG-026 Author(s) :  Baruah, C.C; Gupta, P.P; Amar Nath, Patnaik, G.K. & Dhawan, B.N. Address :  Division of Pharmacology, Central Drug Research Institute, Lucknow - 226 001, Source :  Ind. Journal of Pharmacology v 29/1 feb 1997. Title :  ANTIALLERGIC ACTIVITY OF PICRORHIZA KURROA Abstract :      Picrorhiza kurroa (KATUKI) is used for the treatment hepatic disorders and allergic conditions in Ayurveda.  Picroliv, a standardised fraction isolated from root and rhizome of Picrorhiza kurroa, consisting mainly of iridiod glycosides, picroside 1 and kutkoside was shown to be responsible for its hepatoprotective and immunomodulatory activities.  Its anti-passive cutaneous anaphylaxis and mast cell stablising activities were investigated in present study. In order  to further establish its antiallergic activity, its effect was studied in experimentally induced anaphylactic reaction (Schultz-Dalle phenomenon) and on Konzett-Roessler preparation.  At 12.5 mg/k

Abstract no :  2-1&2-DG-025 Author(s) :  Smith D.E. Salerno J.W., Address :  Department of Physiological and Biological Sciences, Maharishi International University, Fairfield, Iowa 52556, Source :  Prostaglandins Leukotrienes & Essential Fatty Acids. 46(2) : 145 - 50, 1992 Jun. Title :  SELECTIVE GROWTH INHIBITION OF A HUMAN MALIGNANT MELANOMA CELL LINE BY SESAME OIL IN VITRO. Abstract :      Ayurveda, an ancient and comprehensive system of natural medicine, recommends regular topical application to the skin of sesame oil (Tila taila), above all other oils, as a health-promoting procedure.  We examined the effect of sesame oil and several other vegetable oils and their major component fatty acis on the proliferation rate of human normal and malignant melanocytes grwoing at similar rates in serum-free media.  We found that sesame and safflower oils, both of which contain large amounts of linoleate in triglyceride form, selectively inhinited malignant melanoma grwoth over

Abstract no :  2-1&2-DG-024 Author(s) :  Gupta S.K., Zafar R. & Pathase D., Address :  Dept of Pharmacognosy & Phytochemistry, Faculty Pharmacy, Jamia Hamdard, Hamdard University New Delhi - 110 062, Source :  Indian Drugs 34 (8) August  97 . pp 426 Title :  REVIEW ON PHYTOCHEMICAL AND PHARMACOLOGICAL ASPECTS TRIBULUS TERRESTRIS L. Abstract :      The Phyto chemical  and pharmacological studies conduced on Tribules terristrus (Goksura)  up to 1986 have been reviewed.

Abstract no :  2-1&2-DG-023 Author(s) :  Srivastava K.K; Address :  Defence Institute of Physiology & Allied Sciences, Jimarpur, Lucknow Road, Delhi - 110054, Source :  Indian Journal of Natural products Vol. 11 - 1995 Spl. Issue. Title :  ADAPTOGENS IN HIGH MOUNTAINS Abstract :      Area of interest in several oriental medical system including Ayurveda, is that of using food supplements, dietary elements, herbs and minerals for increasing physical endurance and mental performance. There have been described as ‘Adaptogens’ (RASAYANA & VAJIKARANA of Ayurveda). One expermental model is developed with albino rats to study the adaptogenic effect of herbal compound, and ASVAGANDHA. After observing encourasing results in rats the drugs are given to 200 solidiers, who had spent one year at higher altitudes (3000 - 6000 M ht.). The study has shown that psycho-physiological performance, physical performance and sensitive indices of oxygen availability to the tissues were impro

Abstract no :  2-1&2-DG-022 Author(s) :  Bernd Lindemann, Address :  Faculty of Physiology, University of Saarrandes, Homburglsaar, Germany, Source :  Physiological Reviews 6, No. 3 July 1996 pp-719-766 Title :  TASTE RECEPTION Abstract :      Recent research on cellular mechanisms of peripheral taste has difined transduction pathways involving membrane receptors, G proteins, second messengers, and iron channels.  Receptors for organic tastants received much  attention, because they provide the specificity of a response.  Their future cloning will constitute a major advance.  Taste transduction typically utilizes two or more pathways in parallel.  For instance, sweet-sensitive taste cells of the rat appear to respond to sucrose with activation of adenylyl cyclase, followed by adenosine 3’5'-cyclic monophosphate (cAMP) dependent membrane events and Ca21 uptake.  The same cell respond differently to some artificial sweeteners, i.e., with activation of phospholipase C (PlC)

Abstract no :  2-1&2-DG-21 Author(s) :  Singh, R.K.; Gopal Natha, Goel, R.K. & Bhattacharya, S.K. Address :  Departments of Pharmacology and a Microbiology,  Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India, Source :  Indian Journal Experimental Biology Vol. 36, February 1998, pp. 187-191 Title :  PHARMACOLOGICAL ACTIONS OF ABIES PINDROW ROYL. LEAF Abstract :      Petroleum ether (PE), benzene (BE), Chloroform (CE), acetone (AE) and ethanolic (EE) extracts (50-200 or 200 mg/kg, ip or 200 mg/kg, po) of dried Abies pindrow (Talisa bheda) leaves, given 30-45 min before showed significant anti-inflammatory (both against acute and sub-acute  models), analgesic, barbiturate hypnosis potentiation and anti-ulcerogenic activities in rats.  All the extracts except EE exhibited hypotension in immobility in mice indicating some degree of anti-depressant activity.  Only PE exhinited hypotension in dogs blocked by atropine.  Chemically, extracts showed t

Abstract no :  2-1&2-DG-020 Author(s) :  R. Vimala & S.Nagarajan,/ M. Alam, T. Susan & S. Joy, Address :   Department of Chemistry, Bharathidasan University, Tiruchirappalli 620 024, India / Captain Srinivasa Murti Drug Research Institute for Ayurveda, Chennai 600 106, India Source :  Indian Journal of Experimental Biology, Vol. 35, December 1997, pp. 1310-1314 Title :  ANTIINFLAMMATORY AND ANTIPYRETIC ACTIVITY OF MICHELIA CHAMPACA LINN., (WHITE VARIETY), IXORA BRACHIATA ROXB. AND RHYNCHOSIA CANA (WILLD.) D.C. FLOWER EXTRACT Abstract :      Methanolic extracts of the flowers of M. champaca (Champaka), I. brachiata (Bandhu jiva bheda) and R. cana were found to possess antiinflammatory activity against cotton pellet granuloma in rats at a dose level of 100 mg/kg body weight, sc. The latter two drugs showed higher activity (AIA) as compared to that of M. champaca. They reduced the protent, acid phospatase, glutamate pyruvate transaminase and glutamate oxalo-avetate trans

Abstract no :  2-1&2-DG-019 Author(s) :  Rameshwar Dayal, Address :  Chemistry Division, Forest Research Institure, Dehra Dun India, Source :  Indian Forester March, 1997 Title :  CHEMICAL INVESTIGATION OF MEDICINAL PLANTS Abstract :      Since his existence on this planet man has had to depend on Nature for sustenance and survival. Medicinal plants have been used by him to keep himself healthy. According to the studies on ethnomedicine and folk medicine about 2000 species are newly identified as drug yielding plants and are well known for their use in about 4000 drug industries of various Indian systems of medicine. Phytochemical examination of a number of them has been carried out and active ingredients, isolated, identified are being currently used as drugs. Chemical examination of hitherto unexplored medicinal plants will help in discovering new drugs. The paper also includes the list of some pure active principles isolated from plant sources ad used as drugs and chemical

Abstract no :  2-1&2-DG-018 Author(s) :  Rao K.S., Mishra S.H., Address :   Pharmacy Deptt. Faculty of Tech & Engg., Lalabhavan, M S University of Baroda, Vadodara - 390 001, Source :  Indian Drugs 1997, 43(3), 146-8. Title :  OEDEMA SUPPRESSANT ACTIVITY OF THE STEM BARK OF MORINGA PTERYGOSPERMA GAERTN Abstract :      Powedered drug and the different extracts of the stem bark of Moringa pterygosperma Gaertn (SIGRU). (Moringaceae) were studied for their oedema suppressant activity in albino rats.  All the extracts showed peak oedema suppressant activity within two hours of carrageenan injection.  The methanolic extract showed signficant (P) oedema suppressant activity similar to that of indomethacin at  the first hour of carrageenan injection.  These studies, therfore, offer scope for further investigations to substaintiate the claims on this bark.

Abstract no :  2-1&2-BP-017 Author(s) :  Shah, D.C.; Chudhari, B.G.; Vachharajani, Y.R. Address :  Drug Standardization Research Project, CCRAS, Gujarat Ayurveda University, Jamnagar 36 108, Gujarat, India Source :   Sachitra Ayurved, v. 47(12): p. 925-939, 1995. Title :  SAVE ENVIRONMENT-SAVE MEDICINAL TREES-SEARCH HARMLESS FORMULAE. Abstract :      Formulas of drugs containing leaves and bark, heartwood, root and stems of plants and prescribed in 23 different ailments have been described. Plant-saving and plant-damaging formulas have been enlisted separately. Different kinds of preparations using leaves for herbs have been tabulated. Use of plants in different diseases as mentioned in 17 Sanskrit texts have been enumerated. Botanical names of 52 plants whose leaves are mainly used and those of 64 plants whose roots, root-bark, stembark and heartwood etc are used, are enlisted separately.

Abstract no :  2-1&2-BP-016 Author(s) :  Unnikrishnan, P. Address :  Prof.P.S Varier Ayurveda College, Kottakkal, Edarikode 676 501, Kerala, India Source :  Aryavadyan, v. 10(4): p. 258-260, 1997. Title :  EXCERPTS FROM CHIKITSAMANJARI-XXI TREATMENT OF MADATYAYA (ALCOHOLISM). Abstract :      Management of the diseases caused due to the over use of intoxicating agents is dealt with in this issue. Some recipies for mada and moorccha with the old treatment techniques against sannyasa are described. Plant based kashaya drugs which cure madatyaya  has been dealt with. Some of the plants mentioned include; Holastemma dekodien, Fritillaria roylei, Lillium polyphyllum, Polygonatum cirrhifolium, P. vertiillatum, Vigna pilosa, V. radiata, Malaxis nucifera, M. acuminata and  Glycyrrhiza glabra (Yastimadhu) etc.

Abstract no :  2-1&2-BK-015 Author(s) :  Shukla, Y.N.; Archana Rani; Sushil Kumar Address :  Central Institute of Medicinal and Aromatic Plants, Lucknow 226 015, UP, India Source :  Journal of Medicinal and Aromatic Plant Sciences, v. 19(2): p.430-431, 1997. Title :  EFFECT OF TEMPERATURE AND PH ON THE EXTRACTION OF TOTAL ALKALOIDS FROM CATHARANTHUS ROSEUS LEAVES. Abstract :      The effect of temperature on the isolation of total alkaloids from the dried leaves of Catharanthus roseus (Sadapuspa) using the method of partitioning of alkaloid bases and their salts between organic and aqueous phases has been studied. The study revealed that as the temperature at which the isolation process was performed, was increased the yield of alkaloid also increased by 0.30 percent to 0.38 percent. Isolation was also done at two different pH 8.5 and 9.0 and a little effect was observed on the yield of alkaloids; the alkaloid yield was increased by 0.07 percent and 0.13 percent, respectively

Abstract no :  2-1&2-BK-014 Author(s) :  Thankamma, A.; Radhika, L.G. Address :  Drug Standardisation Unit, Ayurveda College Unit Poojappura, Thiruvananthapuram, Kerala, India Source :  Aryavaidyan, v. 10(3): p.177-182, 1997. Title :  STANDARDISATION OF BRAHMIGRITHAM. Abstract :      BRAHMIgritham is a compound consisting of several medicinal plants and is considered to be a good brain tonic, according to Ayurveda text. Ghee is used in this preparation. TLC method is described for the detection of various ingredients. The plants ingredients include the following viz., Piper nigrum (MARICAM), Ipomoea turpethum (Thrivrit), Baliospermum montanum (Danti), Cassia fistula (Aragwadha), Alstonia scholaris (Saptaparna), Embelia ribes (Vidanga). The method employed can be used as one of the methods for standardisation of the drug.

Abstract no :  2-1&2-BK-013 Author(s) :  Sharma, M.L. Address :   Department of ISM&H, Ministry of Health and Family Welfare, Government of India, New Delhi, India Source :   Pharma Times, v. 29(5): p. 35-43, 1997. Title :  GOOD MANUFACTURING PRACTICES (GMP) FOR AYURVEDIC, SIDDHA AND UNANI MEDICINES: DRAFT PROPOSALS: REG.NO.K 11025/1/96-DOC(ISM) DATED 4TH FEBRUARY, 1997. Abstract :      A copy of Good Manufacturing Practices (GMP) for Ayurveda, Siddha and Unani drugs duly approved by Chairman, A.S.H.D.A.B. has been presented.

Abstract no :  2-1&2-BK-012 Author(s) :  Saraswathy, A.; Sankari, R.; Pappa, V.; Veluchamy, G. Address :  Drug Standardisation Research Unit Siddha, Captain Srinivasa Murti Drug Research Institute for Ayurveda, Arumbakkam, Madras 600 106, TN, India Source :  Journal of Research in Ayurveda and Siddha, v. 15 (3-4): p. 178-184, 1994. Title :  STANDARDISATION OF ELATICCURANAM. Abstract :      Elaticcuranam, a Siddha compound formulation containing eight herbal drugs viz., Eugenia aromatica (Lavanga) (flower buds), Piper nigrum (MARICAM) (fruits), Cinnamomum wightii, (flowers), Taxus baccata (Talisa) (leaves),  Manihot utilissima (Sakarkand)  (rhizome), Zingiber officinale (SUNTI) (rhizome),  Elettaria cardamomum (Ela) (seed) and cane sugar, was prepared and chemically analysed to lay down standards. Thin layer chromatographic technique was also employed to characterize the respective chemical constituents. The evolved parameters along with the chemical markers can be used for pr

Abstract no :  2-1&2-BK-011 Author(s) :  Shuxian, L.; Yuebiao, L.; Fang, C.; Donglin, Z.; Yueming, J. Address :  South China Institute of Botany, Academia Sinica, Guangzhou 510 650, China Source :  Journal of Tropical and Subtropical Botany, v. 4(3): p.45-49, 1996. Title :  PHYSIOLOGICAL AND BIOCHEMICAL CHANGES IN POSTHARVEST GARLIC BULBS AND THE TECHNIQUE OF STORAGE. Abstract :      The garlic bulbs Allium sativum (LASUNA) after harvest were stored at low temperature (1-5C), ambient temperature and high temperature (35C), and the subsequent effects of storage on physiological and biochemical changes were examined. Respiratory rate, protein and vitamin C contents gradually increased as the storage period of garlic bulbs progressed at ambient temperature, while sugar and dry matter contents decreased markedly after 2 months of storage, and the germs of garlic bulbs began to sprout. Controlled atmosphere storage (O2:2-5 percent, CO2:8-10 percent) at low temperature (1-5C) obvio

Abstract no :  2-1&2-BK-010 Author(s) :  Price, K.R.; Bacon, J.R.; Rhodes, M.J.C. Address :   Biochemistry Department, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK Source :  Journal of Agricultural and Food Chemistry, v. 45(3): p.938-942, 1997. Title :  EFFECT OF STORAGE AND DOMESTIC PROCESSING ON THE CONTENT AND COMPOSITION OF FLAVONOL GLUCOSIDES IN ONION (ALLIUM CEPA). Abstract :      The stability of the major flavonol glucosides, quercetin 3,4'-O-diglucoside (QDG) and quercetin 4'-O-monoglucoside (QMG), was studied in two varieties of onion (Palandu) that were cured and stored for 6 months under normal commerical conditions and analyzed at regular intervals. Onions were also cooked by bioling in water and by frying in oil under normal domestic conditions. Apart from a 50 percent loss of quercetin 4'-O-monoglucoside during the initial drying process, little change in content and composition was observed over 6 months of storage

Abstract no :  2-1&2-BK-009 Author(s) :  Murthy, C.T.; Krishnamurthy, N.; Ramesh, T.; Rao, P.N.S. Address :   Department of Food Engineering, Central Food Technological Research Institute, Mysore 570 013, Karnataka, India Source :  Journal of Food Science and Technology, v. 33(4): p.299-301, 1996. Title :  EFFECT OF GRINDING METHODS ON THE RETENTION OF BLACK PEPPER VOLATILES. Abstract :      Piper nigrum (MARICAM) was ground at four different feed temperatures viz. 40 degree C, ambient (24 degreeC), 10 degree C and-120 degree C, using hot or chilled water circulation through the grinder jacket or direct injection of liquid nitrogen (LN2)  into the mill along with the feed. The volatile oil content of the product indicated that chilled water and LN2 cooled conditions retained almost same quanity of voaltiles (e.56 ml/100 g and 3.60 ml/100g, respectively) and powder fineness was greater in the case of the latter. The gas chromatographic analysis of the oils showed higher retent

Abstract no :  2-1&2-BK-008 Author(s) :  Shanavaskhan, A.E.; Binu, S.; Unnithan, C.M.; Santhoshkumar, E.S.; Pushpangadan, P. Address :  Tropical Botanic Garden and Research Institute, Pacha-Palode, Thiruvananhapuram 695 562, Kerala, India Source :  Fitoterapia, v. 68(1): p. 69-74, 1997. Title :  DETOXIFICATION TECHNIQUES OF TRADITIONAL PHYSICIANS OF KERALA, INDIA ON SOME TOXIC HERBAL DRUGS. Abstract :      Techniques used to detoxify ten herbal drugs viz., Baliospermum montanum (Danti) (roots, leaves, seeds), Cannabis sativa (BHANGA) (leaves, flowers), Commiphora wightii (GUGGULU) (gum.) Croton tiglium (Jayapaala) (root, stem. leaf, seed), Datura stramonium (Dattura) (leaf, flower, fruit, root), Gloriosa superba (Langali) (tuber), Mucuna pruriens (roots, (KAPIKACCHU) seeds and the hairs covering the pods), Plumbago indica (roots) (CHITRAKA), Semecarpus anacardium (Seed kernels) (Bhavataka) and Strychnos nux-vomica (KUPILU) (seeds) are described. Properties of these drugs are

Abstract no :  2-1&2-BK-007 Author(s) :  Dhar, A.K.; Mir, G.M. Address :  Regional Research Laboratory, Canal Road, Jammu 180 001, JK, India Source :  Journal of Herbs, Spices & Medicinal Plants, v. 4(4): p. 83-90, 1997. Title :  SAFFRON  IN KASHMIR-VI: A REVIEW OF DISTRIBUTION AND PRODUCTION. Abstract :      The production of saffron (Crocus sativus) (Kesara), an important ingredient of Ayurvedic and Unani systems of medicine, occurs primarily in Jammu and Kashmir State. The botany, distribution and trade of this crop along with estimates on production and socioeconomic impacts in Kashmir are discussed.

Abstract no :  2-1&2-BK-006 Author(s) :  Jnanendra Singh; Ram Prakash Address :  Ayurvedic & Unani Laboratory U.P.Government, 32 Sarojini Naidu Marg, Lucknow 226001, UP, India Source :  Indian Drugs, v. 34(6): p.360-361, 1997. Title :  IDENTIFICATION OF SOME AYURVEDIC DRUGS USING I.R.SPECTROPHOTOMETER. Abstract :      Various samples of different Ayurvedic drugs such as SHATSAKARA CHURNA, Spy Cream, DASHAMULARISHTA, ASVAGANDHARISHTHA, ABHAYARISHTHA, TRIPHALACHURNA, SHITOPHALADI CHURNA extracted by chloroform - ether extract, were subjected to IR spectrophotometer. Its absorption peaks and finger print region were compared to standard drugs and the same is reported.

Abstract no :  2-1&2-BK-005 Author(s) :  Jeseph, J.; Raghavan, B.; Nanjundaiah, G.; Shankaranarayana, M.L. Address :  Central Food Technological Research Institute, Mysore 570 013, Karnataka, India . Source :  Journal of Spices and Aromatic Crops, v. 5(2): p.105-110, 1996 Title :  CURING OF LARGE CARDAMOM (AMOMUM SUBULATUM ROXB.): FABRICATION OF A NEW DRYER AND A COMPARATIVE STUDY OF ITS PERFORMANCE WITH EXISTING DRYERS. Abstract :      A simple natural convection dryer that could be easily dismantled and transported was designed, fabricated and field tested in a large cardamom (Amomum subulatum) (Brihadaila) plantation in Sikkim, India. The thermal efficiency of the dryer (5.2 percent) was much higher compared to the traditional curing house dryer (1.8 percent) thus saving substantial fuel. The dryer had a capacity of 300 kg of fresh cardamom capsules and the time taken for drying the fresh capsules to a moisture content of about 10 percent  was 24th which was much less comp

Abstract no :  2-1&2-BK-004 Author(s) :  Shankaranarayana, K.H.; Angadi, V.G.; Rajeevalochan, A.N.; Theagarajan, K.S.; Sarma, C.R.; Rangaswamy, C.R. Address :  Institute of Wood Science and Technology, Bangalore 560 003, Karnataka, India Source :  Current Science, v. 72(4): p. 241-242, 1997 Title :  A RAPID METHOD OF ESTIMATING ESSENTIAL OIL CONTENT IN HEARTWOOD OF SANTALUM ALBUM LINN. Abstract :      Sandalwood (Chandana) oil is generally obtained by hydro or steam distillation of powdered heartwood. Estimation of oil in a small quantity of heartwood powder is difficult by the conventional steam distillation method. However, estimation of oil in a small quantity of heartwood material containing atleast 1 mg of oil is rendered simpler, quicker and fairly accurate by using UV spectrophotometer measuring optical density at 219 nm (max) on hexane extract of sandal powder, and can be carried at any time after sample collection. Hence, this method would be useful in rapid screenin

Abstract no :  2-1&2-BK-003 Author(s) :  Cantalejo, M.J. Address :  Dr.Rainer Wild Foundation, Inder Aue 4,69118 heidelberg, Germany Source :   Journal of Agricultural and Food Chemistry, v. 45(5): p.1853-1860, 1997. Title :  ANALYSIS OF VOLATILE COMPONENTS DERIVED FROM RAW AND ROASTED EARTH-ALMOND (CYPERUS ESCULENTUS L.). Abstract :      Volatile aroma components of raw earth almond (Nagaramusta) and those developed in a roasting process were analyzed by gas chromatography/mass spectrometry to determine the identity of compounds that would indicate the degree of roasting. In all, 143 components (ca.90 percent of the total isolate) were postively identified, of which 138 are reported as earth almond volatiles for the first time. The main flavor compounds identified in raw earth almond were alcohols, whereas in roasted earth almond, the majority of the volatiles identified suggest the flavor formation is via the Maillard reaction, with pyrazines contributing directly to the ro

Abstract no :  2-1&2-BK-002 Author(s) :  Narayana D.B.A; Baba B; and Katiyar C.K. Address :  Dabur Research Foundation, 22, Site IV, Sahibabad - 201010 U.P.. India, Source :   The Eastern pharmasist, September, 1997 pp. 21-27 Title :  HERBAL REMEDIES THROUGH GMP/HACCP TECHNIQUES Abstract :      The need of classical methods and Good manufacturing practices (GMC) in Ayurvedic Herbal medicines are discussed in detail. The authors have suggested to adopt “Hazard Analysis and Critical Control Point” (HACCP) for Ayurvedic drugs also. HACCP has been made a mandatory requirement for the production, handling, storage and distribution of processed foods in their domestic as well as export/import markets. World standard bodies such as Codes Alimentarius Commission, WHO and international organisations such as FAO/UN, WTO etc. have decieded to use HACCP as the basic tool in quality assurance and inspection of processed foods.The back ground, principles, inplemtation of HACCP are discusse

Abstract no :  2-1&2-AG-001 Author(s) :  Houghton, P.J. Skari, K.P.; Tafesse, S. Address :   Pharmacognosy Research Laboratories, Department of Pharmacy, king’s College  London, Manresa Road, London SW3 6LX Source :  Medicines and Foods: The Ethnopharmacological Approach.  2nd European Colloquium on Ethnopharmacology, p. 08, 24-27 March 1993, Heidelberg, Germany Title :  IN VITRO TESTING OF PLANTS USED IN THE INDIAN SUB-CONTINENT FOR TREATING SNAKEBITE. Abstract :      Aqueous extracts of the roots of Rauvolfia serpentina (Sarpagandha) and R.canescens,  Ophiorrhiza mungos (Sarpaksi) and Cassia tora (Chakramarda) which all have a reputation of use against snakebite in the traditional medicine of India and Sri Lanka were tested against carpet viper (Rajamantha) (Echis carinatus, and Naja species venomes. The extracts of Ophirrhiza mungos and Cassia tora both gave a decrease in contracture and an increase in time to twitch block induced by venom and so inhibitory effect on the c

Abstract no :  1-3-ML-180 Author(s) :  Uma Shanker, R. and Ganesayya, K.N. Address :  Department of Crof Physiology, University of Agricultural sciences, Bangalore. Source :  Current Science, Vol. 73, No.2, 25 July 1997. Title :  MAPPING GENETIC DIVERSITY OF PHYLLANTHUS EMBLICA : FOREST GENE BANKS AS A NEW APPROACH FOR IN SITU CONSERVATION OF GENETIC RESOURCES. Abstract :      In this study, authors tried to evaluate the genetic diversity of four populations of P. emblica (AAMALAKI) using isozyme analysis. Based on results, propose stratagies for the long term in-situ conservation of the genetic resources of P. emblica. They introduce the concept of Forest Gene Banks as a vriable alternative to the existing methods of in situ conservation of genetic resources.

Abstract no :  1-3-ML-179 Author(s) :  Mr Claude Pouart Address :  French Institute for Health and Medical Research INSERM and Mr Bertrand Merot and Limagrain bio-sante Source :  Jama-India,. May 1997. Vol.21, No.2 17 Title :  AND NOW, BLOOD FROM TOBACCO Abstract :      The vector chosen to transfect tobacco (Tamaku) cells was a soil bacterium, Agrobacterium tumefacients, that is naturally capable of transmitting part of its genetic make-up to the genome of various plants. The genetic construct was therefore introduced into the bacterium which, in turn, transferred it to the tobacco cells.Tobacco cells modified in this way were then used to grow mature plants. Hemoglobin was detected in the seed and roots of more than half the plants obtained in this way. This human hemoglohin synthesized in all its complexity, was found to fix and release oxygen just like the reference hemoglobin.

Abstract no :  1-3-ML-178 Author(s) :  Masuda, T.; Jitoe, A. and Mabry, T.J. Address :  - Source :  Journal of the American Oil Chemists’ Society 72(9): 1995, 1053-1057. Title :  ISOLATION AND STRUCTURE DETERMINATION OF CASSUMUNARINS A,B, AND C: NEW ANTI-INFLAMMATORY ANTIOXIDANTS FROM A TROPICAL GINGER, ZINGIBER CASSUMUNAR. Abstract :      New antioxidants, cassumunarins A, B and C, were isolated from the rhizomes of Zingiber cassumunar (ARDRAKA BH.), structures were determined, by spectroscopic methods, to be complex curcuminoids. The antioxidant efficiency of cassumunarins was determined by inhibitory activity of autoxidation of linoleic acid in a buffer-ethanol system. The anti-inflammatory effect was measured by inhibition of oedema formation on mouse ear induced by 12-O-tetradecanoylphorbol-13-acetate. Both types of activities were stronger for the cassumunarins than for the curcumin.

Abstract no :  1-3-ML-177 Author(s) :  de Witte, P. Address :  Laboratorium voor Farmaceutische Biologie en Fytoifarmacologie, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Van Evenstraat 4, B-3000 Leuven, Belgium Source :  Phytotherapy Research, v. 10(Suppl.1): p. S144-S146, 1996. Title :  NATURAL PRODUCTS AND NEW TARGETS IN ONCOLOGY. Abstract :      In the last decade, much progress has been made in the understanding of the molecular mechanisms underlying mammalian cell transformation and of the detailed biochemical pathways controlling cell replication. This knowledge is nowadays exploited to create rational, mechanism-based inhibitors of specific biochemical processes that are essential to the malignant phenotype of cancer cells. Several natural products have been shown to exert specific inhibitory activity against aberrant signal transduction. They are presently used as lead compounds for the development of new anticancer drugs.

Abstract no :  1-3-ML-176 Author(s) :  Mathur, R.; Kamal, R. Address :  Laboratory of Plant Physiology and Biochemistry, Department of Botany, University of Rajasthan, Jaipur 302 004, Rajasthan, India Source :  Journal of Phytological Research, v. 7(2): p. 111-116, 1994. Title :  PHYTOCHEMICAL INVESTIGATIONS OF DERRIS INDICA (LAM.) BENETTE IN VIVO AND IN VITRO. Abstract :      Various plant parts and callus cultures raised from seeds of Derris indica (Karanja) on MS medium later transferred on RT medium were collected separately and analysed for their carbohydrates, proteins, lipids, ascorbic acid, pigments and phenols. The callus sample showed a significant high amount of starch as compared to other plant parts. Seeds gave higher recovery of carbohydrates, proteins, lipids and ascorbic acid than callus and other plant parts.

Abstract no :  1-3-ML-175 Author(s) :  Greenberg, E.R.;Baron, J.A.; Karagas, M.R.; Stukel, T.A.; Nierenberg, D.W.; Stevens, M.M.; Mandel, J.S.; Haile, R.W. Address :  Dartmouth Medical School and Norris Cotton Canccer Center, Lebanon Source :  Journal of the American Medical Association, India, v. 19(2): p. 124-128, 1996. Title :  MORTALITY ASSOCIATED WITH LOW PLASMA CONCENTRATION OF BETA CAROTENE AND THE EFFECT OF ORAL SUPPLEMENTATION. Abstract :      Persons whose diets are rich in fruits and vegetables have lower rates of several chronic diseases, most notably cardiovascular conditions and cancer. The lower cardiovascular disease risk is sometimes attributed to consumption of beta carotene, an antioxidant provitamin A found in many fruits and vegetables. These analyses provide no support for a strong effect of supplemental beta carotene in reducing mortality from cardiovascular disease of other causes. Al- though the possibility exists that beta carotene supplementation produc

Abstract no :  1-3-ML-174 Author(s) :  Rapola, J.M.; Virtamo, J.; Hfaukka, J.K.; Heinonen, O.P.; Albanes, D.; Taylor, P.R.; Huttunen, J.K. Address :  National Public Health Institute, Helsinki, Finland Source :  Journal of the American Medical Association, India, v. 19(2): p. 116-123, 1996. Title :  EFFECT OF VITAMIN E AND BETA CAROTENE ON THE INCIDENCE OF ANGINA PECTORIS. Abstract :      The lower cardiovascular disease is some times attributed to consumption of beta-carotene found in many fruits and vegetables. Supplementation with alpha tocopherol was associated with only a minor de crease in the incidence of angina pectoris. Beta carotene had no preventive effect and was associated with a slight increase in the incidencce of angina.