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EFFECT OF PICROLIV ON IMPAIRED DRUG METABOLISM IN CARBON TETRACHLORIDE TOXICATED RATS

Abstract no :  2-1&2-DG-039
Author(s) :  Rastogi, R. & Dhawan, B.N.
Address :  ICMR Centre for advanced Pharmacological Research on Traditional remedies, Biochemistry Division, Central Drug Research Institute, Lucknow - 226 001
Source :  Ind. Journal of Pharmacology v 29/1 feb 1997.
Title :  EFFECT OF PICROLIV ON IMPAIRED DRUG METABOLISM IN CARBON TETRACHLORIDE TOXICATED RATS
Abstract :      Carbon tetrachloride (CCI4) induced hepatotoxicity is a commonly used model for investigating  lipid-peroxidation related tissue injury.  In the present study, a drastic impairment in hepatic drug metabolism was observed in rats 24 hr following administration of CCI4 (1.0 ml/kg, i.p., single) as indicated by decrease in the activities of various microsomal drug metabolising components viz., aminopyrine-N-demethylase, aniline hydroxylase, NADH-cytochrome C-reductase, NADPH-cytochrome C-reductase, cytochrome P450 and glutathione-S-transferase.  Picroliv (an iridoid glycoside fraction obtained from roots and rhizomes of Picrorhiza kurroa) (Katuki) at a dose of 6.0 mg/kg (p.o) for 7 days (6 days before and one day along with CCI4 treatment),  provides significant protection (25-80%) to most of these altered biochemical parameters.  No significant protection was observed in the activity of NADPH Cytochrome C-reductase.

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