Skip to main content

CYCLO-OXYGENASE INHIBITORS FROM SPICES

Abstract no :  2-1&2-DG-050
Author(s) :  Vobalaboina Venkateshwarlu,
Address :  University College of Pharmaceutical Sciences, Kakatiya University, Warangal - 506 009, A.P., India,
Source :  Indian Drugs 34(8) August, 1997.
Title :  CYCLO-OXYGENASE INHIBITORS FROM SPICES
Abstract :      The crude extracts of fresh rhizomes of Zingiber officinale (ginger) (ARDRAKA), dried rhizomes of Curcuma longa (turmeric) ()  and dry fruits of Piper nigrum (black pepeer) (MARICAM), showed potent inhibitory activity against prostaglandin biosynthesizing enzyme (cyclo-oxygenase, PG synthetase) in an in vitro bioassay test. The extracts were fractionated by monitoring the activity to yield [10]-gingerol 1, [6]-gingerol 2 from ginger, 1,7-bis (4-hydroxy-3-methoxyphenyl) 1,6-heptadiene- 3,5-dione (curcumin) 3, phydroxycinnamoylferuloylmethane-1, 6-heptadiene- 3,5-dione 4 from turmeric and piperine 5 from black pepeer. Compounds 1-5 were characterized on the basis of their IR, NMR spectroscopic data. The cyclo-oxygenase inhibitory activity of these compounds 1-5 was determined by an in vitro assay method in horse blood. Flunixin meglumine was used as a standard for comparing the cyclo-oxygenease inhibitory activity. Radioimmunoassay of thromboxane B2  (TxB2) was used to assess the concentration of thromboxane A2 (TxA2) in serum.

Comments

Post a Comment

Popular posts from this blog

A COMPARATIVE STUDY ON HYPOCHOLESTEROLAEMIC EFFECT OF ALLICIN, WHOLE GERMINATED SEEDS OF BENGAL GRAM AND GUGGULIPID OF GUM GUGGLU

Abstract no :  4-1..4-DG-205 Author(s) :  Ghorai, M.; Mandal, S.C.; Pal, M.; Pal, S.P.; Saha, B.P Address :  (Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta 700 032, WB, India) Source :  Phytotherapy Research, v. 14(3): p. 200-202, 2000 Title :  A COMPARATIVE STUDY ON HYPOCHOLESTEROLAEMIC EFFECT OF ALLICIN, WHOLE GERMINATED SEEDS OF BENGAL GRAM AND GUGGULIPID OF GUM GUGGLU Abstract :      The daily use of allicin (active principle from Allium sativum (LASUNA)) and whole germinated Bengal gram (Cicer arietinum (CHANAKA)) seeds for 8 weeks led to a significant decrease in serum cholesterol levels in normal volunteers with no side effects. Guggulipid (gum of Commiphora mukul (GUGGULU)) therapy, significantly (p less than 0.001) reduced the mean serum cholesterol level. Allicin treatment significantly reduced the mean serum cholesterol level. The serum cholesterol value was reduced d...
Post a Comment
Read more

GERMINATED BARLEY FOODSTUFF IMPROVES CONSTIPATION INDUCED BY LOPERAMIDE IN RATS.

Author(s) :  . (Applied Bioresearch Center, Corporate Research and Development Division Kirin Brewery Company Limited, Miyaharacho 3, Takasaki, Gunma  370-1295, Japan), Address :  Kannuchi,0.; Hitomi, Y.; Agata, K.; Nakamura, T.; Fushiki, T Source :   Bioscience, Biotechnology and Biochemistry, v. 62(9): p. 1788-1790, 1998 Title :  GERMINATED BARLEY FOODSTUFF IMPROVES CONSTIPATION INDUCED BY LOPERAMIDE IN RATS. Abstract :      The effects of germinated barley (YAVA) foodstuff (GBF) derived from the aleurone and scutellum fractions of germinated barley low-lignified hemicellulose were examined in Sprague-Dawley rats with constipation induced by Loperamide by addition to the diet (2 mg/kg body weight). Bowel movements were higher in the GBF-fed rats than in the cellulose-fed rats used as control. Fecal water content was also higher in the GBF-fed rats. The concentration of short chain fatty acids in cecal content, especially butyrate, was signi...
Post a Comment
Read more

STUDIES ON ESSENTIAL OILS, PART-14; NATURAL PRESERVATIVES FOR BUTTER

Ayurveda is the science and know how of human living in a better way. It is perfected over thousands of years in India. This blog trying to explore all the secrets Ayurveda in a simple and palatable form and named it as "Ayurvedya". It is wish and grace of Pujya Sadguru Deva. JGD Abstract no :  3-1...4-SV-362 Author(s) :   (Chemistry Dept., Gorakhpur University, Gorakhpur 273 009, UP, India) Address :  Singh, G.:Kapoor, I.P.S; Pandey, S.K. Source :  Journal of Medicinal and Aromatic plant sciences,  v. 20(3): p. 739-739, 1998 Title :  STUDIES ON ESSENTIAL OILS, PART-14; NATURAL PRESERVATIVES FOR BUTTER Abstract :      Essential oils extracted from ten spice materials have been tested to prevent butter deterioration stored at room temperature. Butter oxidation and lypolysis were determined by measuring peroxide and acid values respectively. Most of the oils have been found to possess greater anti-hydrolytic effects than commercial prese...
Post a Comment
Read more