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CYCLO-OXYGENASE INHIBITORS FROM SPICES

Abstract no :  2-1&2-DG-050
Author(s) :  Vobalaboina Venkateshwarlu,
Address :  University College of Pharmaceutical Sciences, Kakatiya University, Warangal - 506 009, A.P., India,
Source :  Indian Drugs 34(8) August, 1997.
Title :  CYCLO-OXYGENASE INHIBITORS FROM SPICES
Abstract :      The crude extracts of fresh rhizomes of Zingiber officinale (ginger) (ARDRAKA), dried rhizomes of Curcuma longa (turmeric) ()  and dry fruits of Piper nigrum (black pepeer) (MARICAM), showed potent inhibitory activity against prostaglandin biosynthesizing enzyme (cyclo-oxygenase, PG synthetase) in an in vitro bioassay test. The extracts were fractionated by monitoring the activity to yield [10]-gingerol 1, [6]-gingerol 2 from ginger, 1,7-bis (4-hydroxy-3-methoxyphenyl) 1,6-heptadiene- 3,5-dione (curcumin) 3, phydroxycinnamoylferuloylmethane-1, 6-heptadiene- 3,5-dione 4 from turmeric and piperine 5 from black pepeer. Compounds 1-5 were characterized on the basis of their IR, NMR spectroscopic data. The cyclo-oxygenase inhibitory activity of these compounds 1-5 was determined by an in vitro assay method in horse blood. Flunixin meglumine was used as a standard for comparing the cyclo-oxygenease inhibitory activity. Radioimmunoassay of thromboxane B2  (TxB2) was used to assess the concentration of thromboxane A2 (TxA2) in serum.

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