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PROTECTIVE EFFECT OF PICROLIV AGAINST RIFAMPICIN INDUCED TOXICITY

Abstract no :  2-1&2-DG-038
Author(s) :  Visen, P.K.S; Saraswati, B; Patnaik, G.K. & Dhawan, B.N;
Address :  ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Division of Pharmacology, Central Dkrug Research Institute, Lucknow,
Source :  Ind. Journal of Pharmacology v 29/1 feb 1997.
Title :  PROTECTIVE EFFECT OF PICROLIV AGAINST RIFAMPICIN INDUCED TOXICITY
Abstract :      The antibiotic rifampicin is widely used in the treatment of tuberculosis and leprosy.  Prolonged use of rifampicin has been reported to cause hepatotoxicity.  Picroliv,  the active constituent of Picrorhizk kurroa (Katuki) has earlier been reported to possess potent hepatoprotective activity against rifampicin toxicity by reversing the changed biochemical parameters significantly.  The present study was aimed to see the effect of picroliv on additional selected parameters of rifampicin hepatotoxicity.  Administration of rifampicin (50 mg/kg, p.o. x 6) alone resulted in 26.32% reduction in bile volume and its major constituents in conscious rat and anaesthetized guinea pig.  It also caused decrease in the viability (50%) and rate of oxygen uptake (51%) in the isolated rat hepatocytes.  Picroliv treatment showed dose dependent (3-12 mg/kg, p.o. x7) protective activity in bile parameters (20-100%)  and also increased the viability of hepatocytes (32-93%) and their rate of oxygen uptake (28-87%) silymarin (6-20 mg/kg), a standard drug, was less active 922-85%) in comparison.

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