Skip to main content

LIVER REGENERATION IN RATS AFTER PARTIAL HEPATECTOMY: INFLUENCE OF PICROLIV

Abstract no :  2-1&2-DG-036
Author(s) :  Dhawan, B.N;
Address :  Division of Pharmacology and Biochemistry, Central Drug Research Institute, Lucknow - 226 001
Source :  Ind. Journal of Pharmacology v 29/1 feb 1997.
Title :  LIVER REGENERATION IN RATS AFTER PARTIAL HEPATECTOMY: INFLUENCE OF PICROLIV
Abstract :      Regeneration of the liver after partial hepatectomy is one of the most popular and frequently used model for the study of cell grwoth and cell differentiation.  Two stages are important in the study of regeneration.  The initial stage, when the cell switch to the proliferating pool and the end stage when the cells return to quiescent Go-phase.  The initial stage is characterized by an increase in number of cell divisions and of all metabolic processes.  The last stage during which mitotic activity decreases to normal levels, has not been throughly investigated.  In the present study the drug metaboilizing  cornponents were estimated during the end stage of liver regeneration i.e. between days 4-30 after 70% removal of this organ and the oral effect of hepatoprotective agent picrollv (6.0 mg/kg) was investigated on those componets.  Microsomal aniline hydroxylase and aminopyrine demethylase, activities was maximally decreased on day 20. Decline in glutathione level and glutathiones transferase activity was evident maximally on day 10.  Decline in cytochrome p 450 content paralleled to that of aniline hydroxylase/aminopyrine demethylase.  Picroliv extracted from KATUKI showed maximum protection in hepatic glutathione content followed by glutathione-s-transferease, aniline hydroxylase, aminopyrine demethylase and cytochrome P450.  These results confirm the antioxidant potential of picroliv and provide additional evidence that it stimulates liver regeneration.

Comments

Post a Comment

Popular posts from this blog

A COMPARATIVE STUDY ON HYPOCHOLESTEROLAEMIC EFFECT OF ALLICIN, WHOLE GERMINATED SEEDS OF BENGAL GRAM AND GUGGULIPID OF GUM GUGGLU

Abstract no :  4-1..4-DG-205 Author(s) :  Ghorai, M.; Mandal, S.C.; Pal, M.; Pal, S.P.; Saha, B.P Address :  (Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta 700 032, WB, India) Source :  Phytotherapy Research, v. 14(3): p. 200-202, 2000 Title :  A COMPARATIVE STUDY ON HYPOCHOLESTEROLAEMIC EFFECT OF ALLICIN, WHOLE GERMINATED SEEDS OF BENGAL GRAM AND GUGGULIPID OF GUM GUGGLU Abstract :      The daily use of allicin (active principle from Allium sativum (LASUNA)) and whole germinated Bengal gram (Cicer arietinum (CHANAKA)) seeds for 8 weeks led to a significant decrease in serum cholesterol levels in normal volunteers with no side effects. Guggulipid (gum of Commiphora mukul (GUGGULU)) therapy, significantly (p less than 0.001) reduced the mean serum cholesterol level. Allicin treatment significantly reduced the mean serum cholesterol level. The serum cholesterol value was reduced d...
Post a Comment
Read more

GERMINATED BARLEY FOODSTUFF IMPROVES CONSTIPATION INDUCED BY LOPERAMIDE IN RATS.

Author(s) :  . (Applied Bioresearch Center, Corporate Research and Development Division Kirin Brewery Company Limited, Miyaharacho 3, Takasaki, Gunma  370-1295, Japan), Address :  Kannuchi,0.; Hitomi, Y.; Agata, K.; Nakamura, T.; Fushiki, T Source :   Bioscience, Biotechnology and Biochemistry, v. 62(9): p. 1788-1790, 1998 Title :  GERMINATED BARLEY FOODSTUFF IMPROVES CONSTIPATION INDUCED BY LOPERAMIDE IN RATS. Abstract :      The effects of germinated barley (YAVA) foodstuff (GBF) derived from the aleurone and scutellum fractions of germinated barley low-lignified hemicellulose were examined in Sprague-Dawley rats with constipation induced by Loperamide by addition to the diet (2 mg/kg body weight). Bowel movements were higher in the GBF-fed rats than in the cellulose-fed rats used as control. Fecal water content was also higher in the GBF-fed rats. The concentration of short chain fatty acids in cecal content, especially butyrate, was signi...
Post a Comment
Read more

STUDIES ON ESSENTIAL OILS, PART-14; NATURAL PRESERVATIVES FOR BUTTER

Ayurveda is the science and know how of human living in a better way. It is perfected over thousands of years in India. This blog trying to explore all the secrets Ayurveda in a simple and palatable form and named it as "Ayurvedya". It is wish and grace of Pujya Sadguru Deva. JGD Abstract no :  3-1...4-SV-362 Author(s) :   (Chemistry Dept., Gorakhpur University, Gorakhpur 273 009, UP, India) Address :  Singh, G.:Kapoor, I.P.S; Pandey, S.K. Source :  Journal of Medicinal and Aromatic plant sciences,  v. 20(3): p. 739-739, 1998 Title :  STUDIES ON ESSENTIAL OILS, PART-14; NATURAL PRESERVATIVES FOR BUTTER Abstract :      Essential oils extracted from ten spice materials have been tested to prevent butter deterioration stored at room temperature. Butter oxidation and lypolysis were determined by measuring peroxide and acid values respectively. Most of the oils have been found to possess greater anti-hydrolytic effects than commercial prese...
Post a Comment
Read more