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CARDIOVASCULAR EFFECTS INDUCED BY VENOM OF SCORPION (BUTHUS TAMULUS) IN DOG

Abstract no :  2-1&2-DG-029
Author(s) :  Patel, B.G; Bhattz, M.I. & Dave, K.C.
Address :  Department of Pharmacology, A.R. College of Pharmacy, Vallabh Vidyanagar-388 120.Torrent Pharmaceutical Pvt. Ltd., and Department of Pharmacology, Smt. N.H.L. Mun. Med. College and V.S. General Hospital, Ahmedabad - 380 006,
Source :  Ind. Journal of Pharmacology v 29/1 feb 1997.
Title :  CARDIOVASCULAR EFFECTS INDUCED BY VENOM OF SCORPION (BUTHUS TAMULUS) IN DOG
Abstract :      The Cardiovascular effects of Lyophilized venom of Scorpion (Buthus tamulus) were investigated in anaesthetized dogs.  The Venom (0.1-0.25 mg/kg i.v.)  produced marked hypertensive effect with bradycardia.  Bradycardia caused by venom was prevented by atropine but not affected by hexamethonium or bilateral vagotomy.  The pressor response caused by venom was not affected by hexamethonium, abolished in reserpine treated dogs or by Phenoxybenzamine.  Higher dose of venom (0.5-1.5 mg/kg i.v.) caused cardiac arrhythmias, depression of ST segment and inversion of T wave.  The results suggest that the hypertensive response followed by i.v. injection of the venom in anaesthetized dogs may probably be due to release of catecholamines from the sympathetic post ganglionic nerve endings.  The bradycardia produced by the venom which was prevented in atropine created dogs may be as a consequence of blocked of muscarinic receptors in the heart.  While ECG changes caused by venom may probably  be due to direct myocardial injuries or due to simultaneous release of catecholamines from sympathetic and acetylcholine from parasympathetic nerve endings.

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