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EVALUATION OF THE HYPOGLYCEMIC ACTIVITY OF A TRADITIONAL HERBAL PREPARATION IN MALE DIABETIC RATS.

Abstract no :  2-1&2-DG-063
Author(s) :  Nada, S.A.; Bashandy, S.A.E.; Negm, S.A.
Address :  Department of Pharmacology, National Research Centre, El-Tahrir St. Dolli, Cairo, Egypt
Source :  Fitoterapia, v.68(3): p. 240-244, 1997.
Title :  EVALUATION OF THE HYPOGLYCEMIC ACTIVITY OF A TRADITIONAL HERBAL PREPARATION IN MALE DIABETIC RATS.
Abstract :      The hypoglycaemic activity of a daily oral dose (1 g/kg) of a 10 percent decoction of an Egyptian widely used folk antidiabetic herbal preparation (PSP) and glibenclamide (Glib) were studied in alloxanized male rats for eight weeks.  PSP is a mixture of equal portions of the powdered seeds of Aloe vera, (KUMARI) Lupinus termis, Trigonella foenum-graecum, (METHIKA) Commiphora myrrha, (Bola) Broania critica and Rheum officinale (Vriksamla). PSP decreased the serum glucose level gradually while Glib exhibited a sharp fall of serum glucose level after 2,4 and 8 weeks of treatment fo diabetic male rats.  PSP inudced a significant decrease of the serum levels of cholesterol, triglycerides,  creatinine and AST.  However, it had no effect on serum ALT level.  PSP also induced a singificant increase in the level of HB, PCV percent, RBC count and a significant decrease of the total WBC count after 4 Weeks of treatment of diabetic male rats.

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