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PICROLIV REGULATES LIPID METABOLISM IN PLASMODIUM BERGHEI INDUCED LIVER DAMAGE IN MASTOMYS CAUCHA

Abstract no :  2-1&2-DG-027
Author(s) :  Chander Ramesh; Khanna, A.K. & Dhawan, B.N.
Address :  Biochemistry Division and ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Research Institute, Lucknow- 226 001,
Source :  Ind. Journal of Pharmacology v 29/1 feb 1997.
Title :  PICROLIV  REGULATES LIPID METABOLISM IN PLASMODIUM BERGHEI INDUCED LIVER DAMAGE IN MASTOMYS CAUCHA
Abstract :      Picroliv, the standardized preparation of iridoid glycosides; plcroside-1 and kutkoside, from Picrorhiza kurroa  (KATUKI) protects liver from damage caused by various hepatotoxins including hepatic damage following Plasmodium berghei (P. berghei) infection in Mastomys Caucha (M.Caucha).  The antioxidant effects and membrane stablishing action of picroliv are reported to contribute to its hepatoprotective activity.  Picroliv stimulates hepatic cholesterol-7A-hydroxylase and restores choleretic activity by increasing the biosynthesis and secretion of bile acids in infected animals.  The liver injury is also accompanied by abnormalities of lipid biosynthesis and metabolism which may be reflected in the plasma lipoprotein spectrum.  Present work reports that P. berghel infection in M. Caucha at 10% parasitaemia suppressed plasma PHLA (30%) and LCAT activity (28%) associated with the increase in the levels of lipid and apoprotein components of serum very low density (36-98%) and lowdensitylipoproteins(30-88%)the liver showed increased levels of lipid and protein, inhibition of TG-lipase activity and suppression of receptor mediated catabolism of low density lipoprotein.  Treatment with picroliv (6mg/kg. p.o) simultaneously with infection for two weeks, significantly reactivated the plasma and liver lipolytic enymes, stimulated the binding of 1125 low  density lipoprotein with liver receptor and enhanced the faecal excretion of bile acids.  These resulted in a return of circulatory lipoproteins towards the normal level.

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