Skip to main content

IN VITRO TESTING OF PLANTS USED IN THE INDIAN SUB-CONTINENT FOR TREATING SNAKEBITE.

Abstract no :  2-1&2-AG-001
Author(s) :  Houghton, P.J. Skari, K.P.; Tafesse, S.
Address :   Pharmacognosy Research Laboratories, Department of Pharmacy, king’s College  London, Manresa Road, London SW3 6LX
Source :  Medicines and Foods: The Ethnopharmacological Approach.  2nd European Colloquium on Ethnopharmacology, p. 08, 24-27 March 1993, Heidelberg, Germany
Title :  IN VITRO TESTING OF PLANTS USED IN THE INDIAN SUB-CONTINENT FOR TREATING SNAKEBITE.
Abstract :      Aqueous extracts of the roots of Rauvolfia serpentina (Sarpagandha) and R.canescens,  Ophiorrhiza mungos (Sarpaksi) and Cassia tora (Chakramarda) which all have a reputation of use against snakebite in the traditional medicine of India and Sri Lanka were tested against carpet viper (Rajamantha) (Echis carinatus, and Naja species venomes. The extracts of Ophirrhiza mungos and Cassia tora both gave a decrease in contracture and an increase in time to twitch block induced by venom and so inhibitory effect on the cobra venom is suggested. The Rauvolfia extracts induced contraction per se and so their effect in the presence of venom could not be assessed.  The test for prolongation of time to blood-clotting induced by E.carinatus showed that all four extracts gave a dose related response.  Cassia tora and  Ophiorrhiza mungos extracts gave the greatest effects when premixed with the venom.  The effect of the Rauvolifa extracts was independent of this factor so they may interfere with the blood-clotting cascade itself.  This indicate that O. mungos and C.tora extracts counteract the venoms of both types of snakes investigated and the effect of the two species of  Rauvolfia on the blood clotting process initiated by Echis carinatus venom indicate that compounds might be present in the extract which have some neutralising effect on the venom of this snake.

Comments

Post a Comment

Popular posts from this blog

EFFECT OF OCIMUM SANCTUM ROOTS EXTRACT ON SWIMMING PERFORMANCE IN MICE

Abstract no :  4-1..4-DG-240 Author(s) :  Maity, T.K.; Mandal, S.C.; Saha, B.P.; Pal, M Address :  ( Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta 700 032, WB, India) Source :  Phytotherapy Research, v. 14(2): p. 120-121, 2000 Title :  EFFECT OF OCIMUM SANCTUM ROOTS EXTRACT ON SWIMMING PERFORMANCE IN MICE Abstract :      Methanol extract, obtained from the roots of Ocimum sanctum (TULASI ) at a dose of 400 mg/kg, i.p. increased the swimming time suggesting a central nervous system stimulant and/or antistress activity. The effect produced by the extract was comparable to that of desipramine, an antidepressant drug.
Post a Comment
Read more

GERMINATED BARLEY FOODSTUFF IMPROVES CONSTIPATION INDUCED BY LOPERAMIDE IN RATS.

Author(s) :  . (Applied Bioresearch Center, Corporate Research and Development Division Kirin Brewery Company Limited, Miyaharacho 3, Takasaki, Gunma  370-1295, Japan), Address :  Kannuchi,0.; Hitomi, Y.; Agata, K.; Nakamura, T.; Fushiki, T Source :   Bioscience, Biotechnology and Biochemistry, v. 62(9): p. 1788-1790, 1998 Title :  GERMINATED BARLEY FOODSTUFF IMPROVES CONSTIPATION INDUCED BY LOPERAMIDE IN RATS. Abstract :      The effects of germinated barley (YAVA) foodstuff (GBF) derived from the aleurone and scutellum fractions of germinated barley low-lignified hemicellulose were examined in Sprague-Dawley rats with constipation induced by Loperamide by addition to the diet (2 mg/kg body weight). Bowel movements were higher in the GBF-fed rats than in the cellulose-fed rats used as control. Fecal water content was also higher in the GBF-fed rats. The concentration of short chain fatty acids in cecal content, especially butyrate, was signi...
Post a Comment
Read more

ANTIOXIDANT ACTIVITY AND TOTAL PHENOLICS IN SELECTED FRUITS, VEGETABLES, AND GRAIN PRODUCTS

Abstract no :  3-1...4-SV-360 Author(s) :   (Food Research program, Agriculture and Agri-Food Canada, Pacific Agri-Food Research Center, Summerland, British Columbia VOH IZO, Canada) Address :  Velioglu, Y.S.; Mazza, G.; Gao, L.; Oomah, B.D Source :  , J. of Agricultural & Food Chemistry, v.46(10): p.4113-7, 1998 Title :  ANTIOXIDANT ACTIVITY AND TOTAL PHENOLICS IN SELECTED FRUITS, VEGETABLES, AND GRAIN PRODUCTS Abstract :      The antioxidant activities and total phenolics of 28 plant products, including sunflower seeds, flaxseeds, wheat germ, buckwheat, and several fruits, vegetables and medicinal plants were determined. The total phenolic content, determined according to the Folin-Ciocalteu method, varied from 169 to 10548 mg/100 g of dry product. Antioxidant activity of methanolic extract evaluated according to the beta-carotene bleaching method expressed as AOX (deltalog A170/min), AA (percent inhibition relative to control), OR...
Post a Comment
Read more