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HEPATOPROTECTIVE EFFECT OF A PROTEIN DERIVED FROM CAJANUS INDICUS SPRENG ON CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN MICE

Abstract no :  2-1&2-DG-031
Author(s) :  Sarmistha Datta, Swati Sinha & Prantosh Bhattacharya,
Address :  Department of Chemistry, Bose Institute, Calcutta-700 009
Source :  Ind. Journal of Pharmacology v 29/1 feb 1997.
Title :  HEPATOPROTECTIVE EFFECT OF A PROTEIN DERIVED FROM CAJANUS INDICUS SPRENG ON CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN MICE
Abstract :      Hepatotoxicity  by different chemicals is well known.  Liver has become the primary target as it is the major site for detoxification.  Treatment with carbon tetrachloride (CCI4) (0.1 ml/100 gms of body weight (b.wt); twice a week) induced acute hepatic necrosis in swiss albino mice (male; b.wt. 30 gms ± 2).  CCI4 induced hepatotoxicity and renal toxicity in albino mice caused significant alteration in the activities of glutamic oxaloacetic transaminase (GOT); glutamic Pyruvic transaminase (GPT); Alkaline and Acid phosphatase and serum bilirubin.  Administration of the protein fraction isolated from the leaves of Cajanus indicus Spreng (AADHAKI)  Concomitant with CCI4; counteracted the action of CCI4on transaminases, phosphatase enzyme showing hepatoprotection.  Daily treatment with a purified protein fraction “X” isolated from the above plant (0.5 ml i.p. conc. 22-25 µg/ml) for a period of 7, 14 and 21 days respectively showed decreased activities of serum transaminases (p<0.01); serum acid and alkaline phosphatases (p<0.01) and decreased levels of serum triglycerides (p<0.05); serurn bilirubin (p<0.001).  Histopathological observations further confirm that the protein fraction “X” produced  significant hepatoprotection against CCI4 induced hepatotoxicity.

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