Abstract no : 2-1&2-DG-022
Author(s) : Bernd Lindemann,
Address : Faculty of Physiology, University of Saarrandes, Homburglsaar, Germany,
Source : Physiological Reviews 6, No. 3 July 1996 pp-719-766
Title : TASTE RECEPTION
Abstract : Recent research on cellular mechanisms of peripheral taste has difined transduction pathways involving membrane receptors, G proteins, second messengers, and iron channels. Receptors for organic tastants received much attention, because they provide the specificity of a response. Their future cloning will constitute a major advance. Taste transduction typically utilizes two or more pathways in parallel. For instance, sweet-sensitive taste cells of the rat appear to respond to sucrose with activation of adenylyl cyclase, followed by adenosine 3’5'-cyclic monophosphate (cAMP) dependent membrane events and Ca21 uptake. The same cell respond differently to some artificial sweeteners, i.e., with activation of phospholipase C (PlC) followed by inositol 1,4,5-trisphosphate (IP3) dependent Ca21 release from intracellular stores. Some bitter tastants block K1channels or initiate the cascade receptor G1 protein, PLG, IP3 and Ca21 release or the cascde receptor d-gustducin, Phosphodiesterase (PDE). cAMP decrease and opening of cAMP-blocked channels. Membrane- permeant bitter tastants may elicit a cellular response by interacting with G protein. PLC. or PDE of the above cascades. Salt taste is initiated by current flowring into the taste cell through cation channels located in the apical membrane. Even though basolateral channels may also contribute following salt diffusion through paracellular pathways). In rodents, the Na specific component of salt taste is typically mediared by apical amiloride-sensitive Na channels, but less specific and not amiloride-sensitive taste components exist in addition. Sour taste may in part be mediated by amiloride-sensitive. Na channels conducting protons. But other mechanisms certainly contribute. Thus the transduction of taste cells generally comprises parallel pathways. Furthermore. The transduction pathways vary with the location of taste buds one the tongue and. of course across species of animals to identify these path way to understand how they are controlled and why they evolved to this complexity are major goals of present research.
Author(s) : Bernd Lindemann,
Address : Faculty of Physiology, University of Saarrandes, Homburglsaar, Germany,
Source : Physiological Reviews 6, No. 3 July 1996 pp-719-766
Title : TASTE RECEPTION
Abstract : Recent research on cellular mechanisms of peripheral taste has difined transduction pathways involving membrane receptors, G proteins, second messengers, and iron channels. Receptors for organic tastants received much attention, because they provide the specificity of a response. Their future cloning will constitute a major advance. Taste transduction typically utilizes two or more pathways in parallel. For instance, sweet-sensitive taste cells of the rat appear to respond to sucrose with activation of adenylyl cyclase, followed by adenosine 3’5'-cyclic monophosphate (cAMP) dependent membrane events and Ca21 uptake. The same cell respond differently to some artificial sweeteners, i.e., with activation of phospholipase C (PlC) followed by inositol 1,4,5-trisphosphate (IP3) dependent Ca21 release from intracellular stores. Some bitter tastants block K1channels or initiate the cascade receptor G1 protein, PLG, IP3 and Ca21 release or the cascde receptor d-gustducin, Phosphodiesterase (PDE). cAMP decrease and opening of cAMP-blocked channels. Membrane- permeant bitter tastants may elicit a cellular response by interacting with G protein. PLC. or PDE of the above cascades. Salt taste is initiated by current flowring into the taste cell through cation channels located in the apical membrane. Even though basolateral channels may also contribute following salt diffusion through paracellular pathways). In rodents, the Na specific component of salt taste is typically mediared by apical amiloride-sensitive Na channels, but less specific and not amiloride-sensitive taste components exist in addition. Sour taste may in part be mediated by amiloride-sensitive. Na channels conducting protons. But other mechanisms certainly contribute. Thus the transduction of taste cells generally comprises parallel pathways. Furthermore. The transduction pathways vary with the location of taste buds one the tongue and. of course across species of animals to identify these path way to understand how they are controlled and why they evolved to this complexity are major goals of present research.
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