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EFFECT OF EUGENOL ON GASTRIC FUNCTION IN RATS

Abstract no :  2-1&2-DG-037
Author(s) :  Vijayalakshmi, R; Y.H. Quadri, S.S. & Deosthale, G;
Address :   Centre for Liver Disease, Owaisi Medical and Research Centre, Kanchanbagh, Hyderabad - 500 258,
Source :  Ind. Journal of Pharmacology v 29/1 feb 1997.
Title :  EFFECT OF EUGENOL ON GASTRIC FUNCTION IN RATS
Abstract :      Eugenol, an active principle of clove, (Lavanga) is an effective secretagogue in rats, causing dose dependent augmentation of gastric secretion. Eugenol, when administered intragastrically at 100 µg/kg body weight, stimulated maximum secretion of gastric free acid and serum pepsinogen, However, at higher concentration it has an inhinitory effect on gastric secretion.  Long term oral treatment of ougenol at a dose of 100 µg/kg body weight per day for three weeks significantly increases the serum pepsinogen levels, which positively correalted with gastric free acid secretion,  The levels of serum mucoprotein and _-antitrypsin remained unchanged.  Histopathological examination of the stomach of experimental animals did not show any damage to mucosal cell.  Thus stimulation of gastric secretion at a low concentration of eugenol, i.e., µg/kg body weight and below, should facilitate digestion.

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