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NATURAL PRODUCTS AND NEW TARGETS IN ONCOLOGY.

Abstract no :  1-3-ML-177
Author(s) :  de Witte, P.
Address :  Laboratorium voor Farmaceutische Biologie en Fytoifarmacologie, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Van Evenstraat 4, B-3000 Leuven, Belgium
Source :  Phytotherapy Research, v. 10(Suppl.1): p. S144-S146, 1996.
Title :  NATURAL PRODUCTS AND NEW TARGETS IN ONCOLOGY.
Abstract :      In the last decade, much progress has been made in the understanding of the molecular mechanisms underlying mammalian cell transformation and of the detailed biochemical pathways controlling cell replication. This knowledge is nowadays exploited to create rational, mechanism-based inhibitors of specific biochemical processes that are essential to the malignant phenotype of cancer cells. Several natural products have been shown to exert specific inhibitory activity against aberrant signal transduction. They are presently used as lead compounds for the development of new anticancer drugs.

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