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EXTRACTS FROM TWO FREQUENTLY CONSUMED SPICES—CUMIN (CUMINUM CYMINUM) AND TURMERIC (CURCUMA LONGA)— INHIBIT PLATELET AGGREGATION AND ALTER EICOSANOID BIOSYNTHESIS IN HUMAN BLOOD PLATELETS.

Abstract no :  2-1&2-DG-042
Author(s) :  Srivastava KC.
Address :  Department of Environmental Medicine, Odense University, Denmark,
Source :   Prostaglandins Leukotrienes & Essential Fatty Acids. 37(1) : 57-64, 1989 Jul.
Title :  EXTRACTS FROM TWO FREQUENTLY CONSUMED SPICES—CUMIN (CUMINUM CYMINUM) AND TURMERIC (CURCUMA LONGA)— INHIBIT  PLATELET AGGREGATION AND ALTER EICOSANOID BIOSYNTHESIS IN HUMAN BLOOD PLATELETS.
Abstract :      In the traditional Indian system of medicine, Ayurveda, several spices and herbs are claimed to possess medicinal properties, such as being antithrombotic, antiatherosclerotic, hypolipidemic, anti-inflammatory etc.  Earlier we have reported  that extracts from several spices behave as antiaggregatory agents and inhibit eicosanoid synthesis.  Similar studies with extracts prepared from cumin (Cuminum cymimum) (Jiraka) and turmeric (Curcuma longa) (HARIDRA) were undertaken.  Ethereal extract of both cumin and turmeric inhinited arachidonate-induced platelet aggregation.  extracts from these spices inhinited thromboxane B2 production from exogenous (14C) arachidonic  acid (AA) in washed platelets; a simultaneous increase in the formation of lipoxygenase-derived products was observed.  Less TxB2 was produced in blood samples treated with turmeric extract when they were allowed to clot.  Turmeric extract inhinited incorporation of (14C) AA into platelet phospholipids and deacyation of AA-labelled phospholipids on  stimulation with calcium ionophore A23187.  Cumin extract was devoid of such effects.  Extracts from the two spices reduced the formation of (14C) TXB2 from AA-labelled platelets when they were challenged with A23187.  The anti-inflammatory property of turmeric may, in part, be explained by its effect on eicosanoid biosynthesis.

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