Abstract no : 2-1&2-DG-051
Author(s) : Jayasekhar.P, Mohanan.P.V, Rathinam.K.,
Address : Priyadasini Institute of Paramedical Sciences, Medical College, Thiruvanathapuram - 695011 & Sree Chitra Tirunal Institute for Medical sciences and Technology, Biomedical Technology Wing, Poojapura, Thiruvanathapuram - 695012, Kerala, India.,
Source : Indian Journal of Pharmacology 1997; 29: pp 426-428.
Title : HEPATO PROTECTIVE ACTIVITY OF ETHYL ACETATE EXTRACT OF ACACIA CATECHU
Abstract : Hepatoprotective activity of ethyl acetate extract of Acacia catechu (Khadira) (katha) is studied in rats. The accute liver damage in albino rats is induced by a single subcutanious administration of 4 ml/kg dose of 50% v/v carbon tetrachloride in olive oil and the chronic liver damage by 2 ml/kg twice a week for 14 days. The hapatoprotective activity was monitered biochemically by estimating serum transminase, serum alkaline phosphstase and seum bilirubin in both the cases after intraperitoneal injection of ethyl acetate extract of ‘katha’ (250mg/kg). The histopathological changes of liver samples were compared with that of control. The extract of katha inhibited the carbon tetrachloride induced liver damage in albino rats at 20mg/kg b.w. as assessed by the biochemical and histopathological values.
Author(s) : Jayasekhar.P, Mohanan.P.V, Rathinam.K.,
Address : Priyadasini Institute of Paramedical Sciences, Medical College, Thiruvanathapuram - 695011 & Sree Chitra Tirunal Institute for Medical sciences and Technology, Biomedical Technology Wing, Poojapura, Thiruvanathapuram - 695012, Kerala, India.,
Source : Indian Journal of Pharmacology 1997; 29: pp 426-428.
Title : HEPATO PROTECTIVE ACTIVITY OF ETHYL ACETATE EXTRACT OF ACACIA CATECHU
Abstract : Hepatoprotective activity of ethyl acetate extract of Acacia catechu (Khadira) (katha) is studied in rats. The accute liver damage in albino rats is induced by a single subcutanious administration of 4 ml/kg dose of 50% v/v carbon tetrachloride in olive oil and the chronic liver damage by 2 ml/kg twice a week for 14 days. The hapatoprotective activity was monitered biochemically by estimating serum transminase, serum alkaline phosphstase and seum bilirubin in both the cases after intraperitoneal injection of ethyl acetate extract of ‘katha’ (250mg/kg). The histopathological changes of liver samples were compared with that of control. The extract of katha inhibited the carbon tetrachloride induced liver damage in albino rats at 20mg/kg b.w. as assessed by the biochemical and histopathological values.
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