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INFLUENCE OF AZADIRACHTA INDICA (NEEM) LEAF EXTRACT ON THE IMMUNOTOXICITY OF STRESS AND XENOBIOTICS IN EXPERIMETAL ANIMALS.

Abstract no :  2-1&2-DG-032
Author(s) :  Ray, A; Banerji, B.D; Koner, B.C. & Sen, P.
Address :  Department of Pharmacology and Biochemistry, U.C.M.S. and G.T.B. Hospital, Shahdara, Delhi - 110 095,
Source :  Indian  Journal of Pharmacology v. 29/1 feb 1997
Title :  INFLUENCE OF AZADIRACHTA INDICA (NEEM) LEAF EXTRACT ON THE IMMUNOTOXICITY OF STRESS AND XENOBIOTICS IN EXPERIMETAL ANIMALS.
Abstract :      A veriety of environmental stressors are known to influence immune function and the present study evaluated the effects of leaf extracts of Azadirachta indica (NIMBA) (Al, Neem) on the immunomodulation induced by restraint stress (RS) and the insecticide, DDT, in rats and mice, In rats immunized with sheep RBC (SRBC), RC (1h/dayx5) exposure suppressed the anti-SRBC antibody titres, and inhinited the increase in footpad thickness after SRBC challenge in mice.  Both these effects were attenuated after oral Al (100mg/kg, x5days) inhibited  the antibody response and suppressed the leucocyte migration inhibition, in tetanus toxoid immunized rats. Al pretreatment (x 6 Weeks) also appreciably   reversed the DDT induced changes in the tests for humoral and cell mediated immunity.  In the interaction studies, prior RS exposure clearly potentiated the otherwise insignificant effect of a subthreshould DDT (200 ppm x 4 weeks)  exposure on the immuno response and this was also reversed by Al pretreatment.  The results indicate that both short and long term Al treatments attenuate the immunotoxicity of environmental/xenobiotic stressors and highlight the immunopotentiating and adaptogenic effect of this indigenous medicinal plant.

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