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PHARMACOLOGICAL ACTIONS OF ABIES PINDROW ROYL. LEAF

Abstract no :  2-1&2-DG-21
Author(s) :  Singh, R.K.; Gopal Natha, Goel, R.K. & Bhattacharya, S.K.
Address :  Departments of Pharmacology and a Microbiology,  Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India,
Source :  Indian Journal Experimental Biology Vol. 36, February 1998, pp. 187-191
Title :  PHARMACOLOGICAL ACTIONS OF ABIES PINDROW ROYL. LEAF
Abstract :      Petroleum ether (PE), benzene (BE), Chloroform (CE), acetone (AE) and ethanolic (EE) extracts (50-200 or 200 mg/kg, ip or 200 mg/kg, po) of dried Abies pindrow (Talisa bheda) leaves, given 30-45 min before showed significant anti-inflammatory (both against acute and sub-acute  models), analgesic, barbiturate hypnosis potentiation and anti-ulcerogenic activities in rats.  All the extracts except EE exhibited hypotension in immobility in mice indicating some degree of anti-depressant activity.  Only PE exhinited hypotension in dogs blocked by atropine.  Chemically, extracts showed the presence of glycosides,  steroids, terpenoids and flavonoids.  They has no anti-bacterial effect.  However, toxicity studies indicated that the extracts had an extended safety index.  The investigations are consonant with some of the uses of this plant in Ayurveda.

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