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ANTIINFLAMMATORY AND ANTIPYRETIC ACTIVITY OF MICHELIA CHAMPACA LINN., (WHITE VARIETY), IXORA BRACHIATA ROXB. AND RHYNCHOSIA CANA (WILLD.) D.C. FLOWER EXTRACT

Abstract no :  2-1&2-DG-020
Author(s) :  R. Vimala & S.Nagarajan,/ M. Alam, T. Susan & S. Joy,
Address :   Department of Chemistry, Bharathidasan University, Tiruchirappalli 620 024, India / Captain Srinivasa Murti Drug Research Institute for Ayurveda, Chennai 600 106, India
Source :  Indian Journal of Experimental Biology, Vol. 35, December 1997, pp. 1310-1314
Title :  ANTIINFLAMMATORY AND ANTIPYRETIC ACTIVITY OF MICHELIA CHAMPACA LINN., (WHITE VARIETY), IXORA BRACHIATA ROXB. AND RHYNCHOSIA CANA (WILLD.) D.C. FLOWER EXTRACT
Abstract :      Methanolic extracts of the flowers of M. champaca (Champaka), I. brachiata (Bandhu jiva bheda) and R. cana were found to possess antiinflammatory activity against cotton pellet granuloma in rats at a dose level of 100 mg/kg body weight, sc. The latter two drugs showed higher activity (AIA) as compared to that of M. champaca. They reduced the protent, acid phospatase, glutamate pyruvate transaminase and glutamate oxalo-avetate transaminase activities in liver and serum. A significant reduction in the ascorbic acid content in adrenals was also observed in drug-treated animals. R. cana was recorded to possess significant antipyretic activity from the first hour of administration. These pharmacological properties may be traced to the presence of flavonoids in the flowers of these plants.

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