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PHARMACOLOGICAL ACTIONS OF PONGAMIA PINNATA ROOTS IN ALBINO RATS

Abstract no :  2-1&2-DG-057
Author(s) :  Singh.R.K, Gopalnath. Acharya.S.B & Goel.R.K
Address :  Department  of Pharmacology & Microbiology, Institute of  Medical Sciences, Banaras hindu University, Varanasi - 221005, India.,
Source :   Indian  Journal of Experimental   Biology,Vol.35,August 1997,pp.831-836.
Title :  PHARMACOLOGICAL ACTIONS OF PONGAMIA PINNATA ROOTS IN ALBINO RATS
Abstract :      Pongamia  pinnata (Karanja)  root  has  been  advocated  in  Ayurveda   for treatment   of  various  inflamatory  and  infective   conditions including ulcers. Sequential petroleum  ether, benzene,chloroform,acetone  and ethanolic extracts  of  P.pinnata root  when  adminstered in the dose of 50 mg/kg. p in  rats  was found   to  have  anti-inflamatory,  analgesic   activity   while pentabarbitone  induced  ‘sleep  time’ was reduced  by  all  the extracts except petroleum ether which, however, enhanced it. They were  also found to posses anti-ulcer effects  when  administered either by ip (45 min. before) or oral route (45 minutes before of for  4 days) against restraint-stress or pylorus-ligated  gastric ulcers  in  rats,  the  maximum  protection  being  afforded   by petroleum ether and ethenol extracts. The mechanism of  antiulcer effect  could either be due to decrease in acid-pepsin  secretion and  augmentation  of mucin secretion as  observed  with  ethanol extract,  while  petoleum ether extract might  be  producing  the effect by vitue of its anti-stress activity.

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