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ANTIFILARIAL ACTIVITY OF MALLOTUS PHILLIPPINENSIS LAM. ON SETARIA CERVIE (NEMATODA: FILAROIDEA) IN VITRO

Abstract no :  2-1&2-DG-053
Author(s) :  Rajender Singh, Singhal.K.C. & Nizam U. Khan
Address :  Department of Pharmacology, J.N. Medical College,  Aligarh  - 202002  &  Department of  Chemistry,  Aligarh  Muslim  University, Aligarh - 202002, India,
Source :  Indian Journal of Physiology and Pharmacology 1997; 41(40  : pp.397-403.
Title :  ANTIFILARIAL  ACTIVITY OF MALLOTUS PHILLIPPINENSIS  LAM.  ON SETARIA CERVIE (NEMATODA: FILAROIDEA) IN VITRO
Abstract :      The effect of aqueous and alcoholicc extracts of the  leaves of Mallotus philippinensis (Lam.) Muell. Arg. (Kampillaka)  was studied on  the spontaneous  movements of the whole worm and nerve-muscle  (n.m.) preparation of Setaria cervi and the survival of microfilariae in vitro.  Both  the  extracts  caused  inhibition  of   spontaneous motility  of  whole  worm and the n.m. preparation of S.cervi charecterised by intial stimulation followed by  depression of amplitude.  The  tone and rate of contractions remained  visibly uneffected.  Aqueous extract  at higher  concentration showed immediate  reduction  in  tone.  The  concentration  required  to inhibit  the movements of n.m. preparation was 1/5th  for  aqueous and  1/11th for alcoholic extract compared to that for the  whole worm,   suggesting   a  cuticular   permiability  barrier.   The stimulatory  response  of  acetylcholine ws  blocked  by  aqueous extract  on whole worm movements. On the microfialriae  the  LC50 and LC90 were 18 and 20 ng/ml for aqueous and 12 and 15 mg/ml for alcoholic extracts respectively.

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