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ANTIHYPERGLYCAEMIC ACTIVITY OF NEEM LEAF EXTRACT IN STREPTOZOTOCIN INDUCED NONINSULIN DEPENDENT DIABETES MELLITUS

Abstract no :  2-1&2-DG-033
Author(s) :  Kapur Ankur & Srinivasan, B.P
Address :  .Department of Pharmacology, College of Pharmacy, New Delhi,
Source :  Ind. Journal of Pharmacology v 29/1 feb 1997.
Title :  ANTIHYPERGLYCAEMIC ACTIVITY OF NEEM LEAF EXTRACT IN STREPTOZOTOCIN INDUCED NONINSULIN DEPENDENT DIABETES MELLITUS
Abstract :      The present study explores the effect of Neem (Nimba) Leaf Extract (NLE) in Non-Insulin dependent diabetes mellitus (NIDDM).  NIDDM was induced by interperitoneal injection streptozotocin (STZ) at a dose level of 90 mg/kg to 2 day old neonatal rats.  After 6 weeks of STZ injection, rats were grouped as non-diabetic, diabetic, neem leaf extract (1.g/Kg, p.o.), glibenclamide (0.025 mg/kg, p.o.) and metformin (200 mg/kg, p.o) treated groups.  The above treatment was continued for 6 weeks by daily oral dosing every morning.  Thereafter blood glucose estimation done by “glucose oxidase method”.  Both NLE and gliben clamide showed an `extremely significant’ fall (p=0.0001) while metformin showed a `very significant’ fall (p=0.0002) in blood glucose level.  It is thus suggested that NLE has a potenital role in treatment of NIDDM.

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