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ANTIFERTILITY ACTIVITY OF NIOSOMAL HPßCD-PLUMBAGIN COMPLEX

Abstract no :  2-1&2-DG-046
Author(s) :  Souza R.D.; Singh, U.V.; Aithal, K.S. & Udupa, M.*
Address :   Department of pharmaceutics, College of Pharmaceutical Sciences, Manipal 576 119, Karnataka,
Source :  Indian J. Pharm. Sci., 1998, 60(1) pp. 36-40
Title :  ANTIFERTILITY ACTIVITY OF NIOSOMAL HPßCD-PLUMBAGIN COMPLEX
Abstract :      Inclusion complex of drug with hydroxyl propyl  betacyciodextrin (HPßCD) was prepared with a view  to increase the efficacy and soiubility of plumbagin the active constituent of Plumbago zeylanicum (CHITRAKA).  The complex was entrapped in the aqueous layer of niosomes and evaluated for antifertility activity.  This in turn was compared with niosomes of the plain drug where entrapment was possible in the lipid layer.  Given Intraperitoneally at a dose of 5 mg/kg the niosomes of the drug complex showed promising antifertility activity when compared to the control and niosomes with lipid layer  entrapment.  Although complex showed lower entrapment efficiency over the plain drug the stability and antifertility activity was markedly increased.

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