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PROTECTIVE EFFECT OF PICROLIV AGAINST ALCOHOL INDUCED HEPATOTXICITY IN RAT

Abstract no :  2-1&2-DG-030
Author(s) :  Saraswat, B; Visen, P.K.S; Patnaik, G.K. & Dhawan, B.N.
Address :  ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Division of Pharmacology, Central Drug Research Institute, Lucknow, India
Source :  Indian  Journal of Pharmacology v 29/1 feb 1997.
Title :  PROTECTIVE EFFECT OF PICROLIV AGAINST ALCOHOL INDUCED HEPATOTXICITY IN RAT
Abstract :      In order to develop herbal, hepatop protective agent for treatment  of alcohol induced liver disorders, protective activity of picroliv the active  constituent isolated form the plant Picrorhiza kurroa (KATUKI) was evaluated against ethanol induced hepatic injury.  Alcohol feeding (3.75 g/kg x 45 days) produced 25 to 90% alteration in selected biochemical serum (GOT. GPT and ALP) and liver markers (Lipid, glycogen and protein)  Further, it also resulted in 41 to 52% reduction in viability (as assessed by trypan blue exclusion and rate of O2 uptake) as well as in ADH and ALDH levels of rat hepatocytes (exvivo). Alcohal also induced cholestasis (45-50%) as indicated by ren bile volume, bile salts and bile acids.  Simultaneous treatment with Picroliv (6mg/kg p.o. x 45 days) significantly restored (67-94%) the altered biochemical parameters in serum, liver and isolated hepatic cells. It also restored the viability of hepatocytes.  There was improvement in biliary secretion.  Picroliv was found to be more potent than silymarin, a standard hepatoprotective agent.

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