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SELECTIVE GROWTH INHIBITION OF A HUMAN MALIGNANT MELANOMA CELL LINE BY SESAME OIL IN VITRO

Abstract no :  2-1&2-DG-025
Author(s) :  Smith D.E. Salerno J.W.,
Address :  Department of Physiological and Biological Sciences, Maharishi International University, Fairfield, Iowa 52556,
Source :  Prostaglandins Leukotrienes & Essential Fatty Acids. 46(2) : 145 - 50, 1992 Jun.
Title :  SELECTIVE GROWTH INHIBITION OF A HUMAN MALIGNANT MELANOMA CELL LINE BY SESAME OIL IN VITRO.
Abstract :      Ayurveda, an ancient and comprehensive system of natural medicine, recommends regular topical application to the skin of sesame oil (Tila taila), above all other oils, as a health-promoting procedure.  We examined the effect of sesame oil and several other vegetable oils and their major component fatty acis on the proliferation rate of human normal and malignant melanocytes grwoing at similar rates in serum-free media.  We found that sesame and safflower oils, both of which contain large amounts of linoleate in triglyceride form, selectively inhinited malignant melanoma grwoth over normal melanocytes whereas coconut, olive and mineral oils, which contain little or no linoleate as triglyceride, did not.  These oils were tested at a range of 10-300 micrograms/ml.  We found that of the fatty acids tested, only linoleic acid was selectively inhinitory while palmitic and oleic were not.   These fatty acids were tested in the range of 3 -100 micrograms/ml.  These results suggest that certain vegetable oils rich in linoleic acid, such as the sesame oil,  recommended for topical use by Ayurveda, may contain selective antineoplastic properties which are similar to those demonstrated for essential polyunsaturated fatty acids and their metabolites.  This suggests that whole vegetable oils may have potential clinical usefulness.

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