AAMRA Allied Ayurveda Medical Research Abstracts

Abstract no :  4-1..4-DG-096 Author(s) :  Kamat, J.P.; Boloor, K.K.; Devasagayam, T.P.A.; Venkatachalam, S.R Address :  (Cell Biology Division, Bhabha Atomic Research Centre, Mumbai 400 085, Maharashtra, India) Source :   Journal of Ethnopharmacology, v. 71(3): p. 425-435, 2000 Title :  ANTIOXIDANT PROPERTIES OF ASPARAGUS RACEMOSUS AGAINST DAMAGE INDUCED BY GAMMA-RADIATION IN RAT LIVER MITOCHONDRIA Abstract :      The possible antioxidant effects of crude extract and a purified aqueous fraction of Asparagus racemosus (SATAVARI) against membrane damage induced by the free radicals generated during gamma-radiation were examined in rat liver mitochondria. gamma-Radiation, in the dose range of 75-900Gy, induced lipid peroxidation as assessed by the formation of thiobarbituric acid reactive substances (TBARS) and lipid hydro peroxides (LOOH). An active fraction of A. racemosus extract consisting of polysaccharides (termed as P3) was found to be e...

Abstract no :  4-1..4-DG-097 Author(s) :  Kirn, Y.H.; Yang, H.E.; Kirn, J.H.; Heo, M.Y.; Kim, H.P Address :  (College of Pharmacy, Kangwon National University, Chunchon 200-701, Korea) Source :  Archives of Pharmacal. Research, v. 23(4): p. 396-400, 2000 Title :  PROTECTION OF THE FLOWERS OF PRUNUS PERSICA EXTRACT FROM ULTRAVIOLET B-INDUCED DAMAGE OF NORMAL HUMAN KERATINOCYTES Abstract :      Ethanol extract of the flowers of Prunus persica (AARUKA) (Ku-35; 100-1,000 microg/ml) inhibited the amount of14C-arachidonic acid/metabolites release from UVB-irradiated keratinocytes. Ku-35 also exhibited the protective activity against UV-induced cytotoxicity of keratinocytes and fibroblasts. In addition, Ku-35 was revealed to protect UVB-induced erythema formation using guinea pigs in preliminary in vivo study. The flowers of P. persica extract have been suggested to be beneficial for protecting UV-induced skin damage when topically applied.

Abstract no :  4-1..4-DG-098 Author(s) :  Konrad, L.; Muller, H.H.; Lenz, C.; Laubinger, H.; Aumller, C.; Lichius, J.J Address :  (Department of Anatomy and Cell Biology, Philipps-Universitat Marburg, Marburg, Germany) Source :  Planta Medica, v. 66(1): p. 44-47, 2000 Title :  ANTIPROLIFERATIVE EFFECT ON HUMAN PROSTATE CANCER CELLS BY A STINGING NETTLE ROOT (URTICA DIOICA)EXTRACT Abstract :      A concentration-dependent and significant (p greater than 0.05) antiproliferative effect of the root extract Urtica dioica (VRISCHIYA SAKA BH.) was observed only on LNCaP cells during 7 days, whereas stromal cell growth remained unaltered. The inhibition was time-dependent with the maximum of growth reduction (30 percent) at a concentration of I .OE-6 mg/ml on day 5 compared to the untreated control. On day 4 and 6, the reduction in proliferation of LNCaP cells showed the minimal effective dose atO.IE-9 mg/ml. No cytotoxic effect of ME-20 on cell pro...

Abstract no :  4-1..4-DG-099 Author(s) :  Lee, M.J.; Lee, O.H.; Yoon, S.H.; Lee, S.K, Chung, M.H.; Park, Y.I.; Sung, O.K.; Choi, J.S.; Kirn,K.W Address :  ( Department of Molecular Biology, Pusan National University, Pusan 609735, Korea) Source :   Archives of Pharmacal. Research, v. 21(3): p. 260-265, 1998 Title :  IN VITRO ANGIOGENIC ACTIVITY OF ALOE VERA GEL ON CALF PULMONARY ARTERY ENDOTHELIAL (CPAE) CELLS Abstract :      The most active fraction (F3) obtained from dichloromethane extract of Aloe vera (KUMARI) gel by partitioning between hexane and 90 percent aqueous methanol increased the proliferation of CPAE cells. In addition, F3 fraction induced CPAE cells to invade type I collagen gel and form capillary-like tube through in vitro angiogenesis assay, and increased the invasion of CPAE cells into matrigel through in vitro invasion assay. F3 fraction enhanced mRNA expression of urokinase-type MMP in CPAE cells whereas the expression o...

Abstract no :  4-1..4-DG-100 Author(s) :  Mahapatra, B Address :  (Dravyaguna, Gopabandhu Ayurveda Mahavidyalaya, Pun 752 002, Orissa, India) Source :  Journal of Research in Ayurveda and Siddha, v. 18(3-4): p. 89-96, 1997 Title :  HYPOGLYCEMIC ACTIVITY OF COSCINIUM FENESTRATUM (GAERTN.) COLEBR Abstract :      Decoction of the stems of Coscinium fenestratum (DARUHARIDRA BH.) was fed to fasting rabbits in order to detect its potential hypoglycemic activity. Coscinium in 4g/kg body weight showed the maximum potency of 73.75 percent as percentage of tolbutamide at the 5th hour of feeding. Coscinium in 2g/kgand 8g/kg did not show any significant result. In G.T.T. studies in rabbit, Coscinium in 4g/kg and also in 8g/kg bodyweight showed a pattern of activity which is comparable to that of tolbutamide 250 mg/kg body weight. On alloxan induced diabetic rabbits Coscinium in 2g/kg, 4g/kg and8g/kg body weight exhibited a significant hypoglycaemic acti...

Abstract no :  4-1..4-DG-101 Author(s) :  Mandal, A.; Karmakar, R.; Bandyopdhyay, S.; Chatterjee, M Address :  (Department of Pharmaceutical Technology, Division of Biochemistry, Jadavpur University, Calcutta 700 032, WB, India) Source :  Archives of Pharmacia Research, v. 21(3): p. 223-230, 1998 Title :  ANTIHEPATOTOXIC POTENTIAL OF TRIANTHEMA PORTULACASTRUM IN CARBON TETRACHLORIDE-INDUCED CHRONIC HEPATOCELLULAR INJURY IN MICE: REFLECTION IN HEMATOLOGICAL, HISTOLOGICAL AND BIOCHEMICAL CHARACTERISTICS Abstract :      The administration of ethanolic extract of Trian themaportulacastrum (at 100 or 150 mg/kg) restored the CC14-in-duced alterations of the hematological parameters to the normal level. The extract of T. portulacastrum elicited a marked protection against CC14-induced hepatotoxicity as indicated by the several hematological parameters, related indices of formed elements, and different fractions of plasma protein. The dose- antihepa...

Abstract no :  4-1..4-DG-102 Author(s) :  McPartland, J.M Address :  (Department of Family Practice, University of Vermont College of Medicine, 53Washington Street Extension, Middlebury, VT 05753,USA) Source :  Journal of Cannabis Therapeutics, v. 1(1):p. 71-83, 2001 Title :  CANNABIS AND EICOSANOIDS : A REVIEW OF MOLECULAR PHARMACOLOGY Abstract :      Many constituents of Cannabis exhibit beneficial anti-inflammatory properties, such as delta-tetrahydrocannabinol (THC) in marijuana and gamma-linolenic acid (GLA) in hemp seed oil. The effects of these Cannabis constituents on eicosanoid metabolism are reviewed. THC and GLA modulate the arachidonic acid cascade, inhibiting the production of series 2 prostaglandins and series 4 leukotrienes. Cannabinoid receptor-as well as nonreceptor mediated signal transduction pathways appear lobe involved. It is proposed that THC acts as a selectivecyclooxygenase-2 (COX-2) - inhibitor.