Skip to main content

CANNABIS AND EICOSANOIDS : A REVIEW OF MOLECULAR PHARMACOLOGY

Abstract no :  4-1..4-DG-102
Author(s) :  McPartland, J.M
Address :  (Department of Family Practice, University of Vermont College of Medicine, 53Washington Street Extension, Middlebury, VT 05753,USA)
Source :  Journal of Cannabis Therapeutics, v. 1(1):p. 71-83, 2001
Title :  CANNABIS AND EICOSANOIDS : A REVIEW OF MOLECULAR PHARMACOLOGY
Abstract :      Many constituents of Cannabis exhibit beneficial anti-inflammatory properties, such as delta-tetrahydrocannabinol (THC) in marijuana and gamma-linolenic acid (GLA) in hemp seed oil. The effects of these Cannabis constituents on eicosanoid metabolism are reviewed. THC and GLA modulate the arachidonic acid cascade, inhibiting the production of series 2 prostaglandins and series 4 leukotrienes. Cannabinoid receptor-as well as nonreceptor mediated signal transduction pathways appear lobe involved. It is proposed that THC acts as a selectivecyclooxygenase-2 (COX-2) - inhibitor.

Comments

Post a Comment

Popular posts from this blog

EFFECT OF OCIMUM SANCTUM ROOTS EXTRACT ON SWIMMING PERFORMANCE IN MICE

Abstract no :  4-1..4-DG-240 Author(s) :  Maity, T.K.; Mandal, S.C.; Saha, B.P.; Pal, M Address :  ( Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta 700 032, WB, India) Source :  Phytotherapy Research, v. 14(2): p. 120-121, 2000 Title :  EFFECT OF OCIMUM SANCTUM ROOTS EXTRACT ON SWIMMING PERFORMANCE IN MICE Abstract :      Methanol extract, obtained from the roots of Ocimum sanctum (TULASI ) at a dose of 400 mg/kg, i.p. increased the swimming time suggesting a central nervous system stimulant and/or antistress activity. The effect produced by the extract was comparable to that of desipramine, an antidepressant drug.
Post a Comment
Read more

GERMINATED BARLEY FOODSTUFF IMPROVES CONSTIPATION INDUCED BY LOPERAMIDE IN RATS.

Author(s) :  . (Applied Bioresearch Center, Corporate Research and Development Division Kirin Brewery Company Limited, Miyaharacho 3, Takasaki, Gunma  370-1295, Japan), Address :  Kannuchi,0.; Hitomi, Y.; Agata, K.; Nakamura, T.; Fushiki, T Source :   Bioscience, Biotechnology and Biochemistry, v. 62(9): p. 1788-1790, 1998 Title :  GERMINATED BARLEY FOODSTUFF IMPROVES CONSTIPATION INDUCED BY LOPERAMIDE IN RATS. Abstract :      The effects of germinated barley (YAVA) foodstuff (GBF) derived from the aleurone and scutellum fractions of germinated barley low-lignified hemicellulose were examined in Sprague-Dawley rats with constipation induced by Loperamide by addition to the diet (2 mg/kg body weight). Bowel movements were higher in the GBF-fed rats than in the cellulose-fed rats used as control. Fecal water content was also higher in the GBF-fed rats. The concentration of short chain fatty acids in cecal content, especially butyrate, was signi...
Post a Comment
Read more

ANTOXIDANTS IN GRAPES AND GRAPE JUICES AND THEIR POTENTIAL HEALTH EFFECTS

Ayurveda is the science and know how of human living in a better way. It is perfected over thousands of years in India. This blog trying to explore all the secrets Ayurveda in a simple and palatable form and named it as "Ayurvedya". It is wish and grace of Pujya Sadguru Deva. JGD Abstract no :  3-1...4-SV-368 Author(s) :  (Dept. of Food Science and Technology, University of California, Davis, CA 95616, USA) Address :  Frankel, E.N.; Meyer, A.S Source :   Pharmaceutical Biology, v. 36 (Suppl.): p.14-20, 1998 Title :  ANTOXIDANTS IN GRAPES AND GRAPE JUICES AND THEIR POTENTIAL HEALTH EFFECTS Abstract :      The review summarizes data on the antioxidant activity of fresh table and wine grapes and commercial grape juices. The activities are discussed in reference to the phenolic compounds involved (anthocyanins, flavonols, flavan-3-oils, hydroxy-benezoates, hydroxycinnamates), their antioxidant mechanisms, and potential health effects. Extracts ...
Post a Comment
Read more