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ANTIPROLIFERATIVE EFFECT ON HUMAN PROSTATE CANCER CELLS BY A STINGING NETTLE ROOT (URTICA DIOICA)EXTRACT

Abstract no :  4-1..4-DG-098
Author(s) :  Konrad, L.; Muller, H.H.; Lenz, C.; Laubinger, H.; Aumller, C.; Lichius, J.J
Address :  (Department of Anatomy and Cell Biology, Philipps-Universitat Marburg, Marburg, Germany)
Source :  Planta Medica, v. 66(1): p. 44-47, 2000
Title :  ANTIPROLIFERATIVE EFFECT ON HUMAN PROSTATE CANCER CELLS BY A STINGING NETTLE ROOT (URTICA DIOICA)EXTRACT
Abstract :      A concentration-dependent and significant (p greater than 0.05) antiproliferative effect of the root extract Urtica dioica (VRISCHIYA SAKA BH.) was observed only on LNCaP cells during 7 days, whereas stromal cell growth remained unaltered. The inhibition was time-dependent with the maximum of growth reduction (30 percent) at a concentration of I .OE-6 mg/ml on day 5 compared to the untreated control. On day 4 and 6, the reduction in proliferation of LNCaP cells showed the minimal effective dose atO.IE-9 mg/ml. No cytotoxic effect of ME-20 on cell proliferation was observed. The antiproliferative effect of ME-20 of stinging nettle roots indicates the presence of a biologically active compounds in the extract.

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