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HYPOGLYCEMIC ACTIVITY OF COSCINIUM FENESTRATUM (GAERTN.) COLEBR

Abstract no :  4-1..4-DG-100
Author(s) :  Mahapatra, B
Address :  (Dravyaguna, Gopabandhu Ayurveda Mahavidyalaya, Pun 752 002, Orissa, India)
Source :  Journal of Research in Ayurveda and Siddha, v. 18(3-4): p. 89-96, 1997
Title :  HYPOGLYCEMIC ACTIVITY OF COSCINIUM FENESTRATUM (GAERTN.) COLEBR
Abstract :      Decoction of the stems of Coscinium fenestratum (DARUHARIDRA BH.) was fed to fasting rabbits in order to detect its potential hypoglycemic activity. Coscinium in 4g/kg body weight showed the maximum potency of 73.75 percent as percentage of tolbutamide at the 5th hour of feeding. Coscinium in 2g/kgand 8g/kg did not show any significant result. In G.T.T. studies in rabbit, Coscinium in 4g/kg and also in 8g/kg bodyweight showed a pattern of activity which is comparable to that of tolbutamide 250 mg/kg body weight. On alloxan induced diabetic rabbits Coscinium in 2g/kg, 4g/kg and8g/kg body weight exhibited a significant hypoglycaemic activity. This result was at 5th hour for 2g/kg dose, both at3rd and 5th hour for 4g/kg dose and at 1st hour for 8g /kgbody weight dose while for tolbutamide it was not significant statistically.

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