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THE CYTOLYTIC EFFECT OF A GLYCOCONJUGATE EXTRACTED FROM CORMS OF SAFFRON PLANT (CROCUS SATIVUS) ON HUMAN CELL LINES IN CULTURE

Abstract no :  4-1..4-DG-089
Author(s) :  Escribano, J.; Jose, M.; Diaz-Guerra, M.;Riese, H.H.; Alvarez, A.; Proenza, R.; Fernandez, J.A
Address :  (Seccion de Bioteenologia, IDR, Universidad de Castilla-LaMancha, Albacete, Spain)
Source :  Planta Medica., v.66(2): p. 157-162, 2000
Title :  THE CYTOLYTIC EFFECT OF A GLYCOCONJUGATE EXTRACTED FROM CORMS OF SAFFRON PLANT (CROCUS SATIVUS) ON HUMAN CELL LINES IN CULTURE
Abstract :      Corms of Crocus sativus (KUMKUMAM) L.(Iridaceae) contain a glycoconjugate, proteoglycan which cause plasma membrane damage, allowing movements of both calcium and macro-molecules, and leading to cell lysis. Analysis of DNA fragmentation showed that cell death was not mediated by apoptosis. This molecule is active against human tumor cells derived from fibro sarcoma, cervical epithelioid carcinoma and breast carcinoma, with IC50 values of 7, 9 and 22microg/ml, respectively. The proteoglycan is about 8 times more cytotoxic for malignant cells than for their normal counterparts. In addition, 100 microg/ml of proteoglycan produced 50 percent in vitro lysis of normal human erythrocytes, whereas 320 microg/ml. induced about 60 percent cell death on cultured human hair follicles. These results suggest a distinctive cytotoxic activity of this molecule on different human cell types.

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