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IN VITRO STUDIES ON THE SELECTIVE CYTOTOXIC EFFECT OF CROCETIN AND QUERCETIN

Abstract no :  4-1..4-DG-094
Author(s) :  Jagadeeswaran, R.; Thirunavukkarasu, C.; Gunasekaran, P.; Ramamurthy, N.; Sakthisekaran, D
Address :  (Department of Medical Biochemistry, Dr.A.L.M.PG Institute of Basic Medical Sciences, Taramani Campus, University of Madras, Chennai 600 113, TN, India)
Source :  Fitoterapia, v. 71(4): p. 395-399, 2000
Title :  IN VITRO STUDIES ON THE SELECTIVE CYTOTOXIC EFFECT OF CROCETIN AND QUERCETIN
Abstract :      Crocetin, a carotenoid present in red stigmatic lobes of Crocus sativus (KUMKUMAM) (5-20 microg/ml), quercetin (10-40 microg/ml), and cisplatin (60-180 microg/ml) used as a positive control drug, were tested against human rhabdomyosarcoma (RD) cells and African green monkey kidney (Vero) cells. The cell viability, morphological changes, and lactate dehydrogenize activity were assessed. RD cell growth was found to be inhibited dose dependently by the three tested compounds. Morphological observation by phase contrast microscopy revealed that both crocetin and quercetin caused intense damage only on the malignant (RD) cells, whereas mild toxic effect was seen with cisplatin also on normal (Vero) cells.

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