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IMMUNOMODULATORY EFFECT OF ALBIZZIA LEBBECK

Abstract no :  4-1..4-DG-078
Author(s) :  Barua, C.C.; Gupta, P.P.; Patnaik, G.K.;Misra-Bhattacharya, S.; Goel, R.K.; Kulshrestha, D.K.; Dubey, M.P.; Dhawan, B.N
Address :   (Division of Phamacology, Central Drug Research Institute, Lucknow, UP, India)
Source :  Pharmaceutical Biology, v. 38(3): p. 161-166, 2000
Title :  IMMUNOMODULATORY EFFECT OF ALBIZZIA LEBBECK
Abstract :      The hot aqueous extract of the bark of Albizzia lebbeck (SIRISHA) and its butanolic fraction were administered once daily for one week in mice, immunized previously with sheep red blood cells (SRBC). At the dose levels tested (6.25, 12.5 and 25 mg/kg.p.o.). A lebbeck treated mice developed higher serum antibody titers compared to the vehicle treated group and the effect was comparable to the standard drug muramyldipeptide (MDP). Delayed type hypersensitivity response was suppressed in SRBC immunized mice treated with A. lebbeck extract. The macrophage migration index remained unaltered in both mice and rats. These results are discussed in the light of possible immunopotentiating effects of A. lebbeck.

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