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CHEMO PREVENTIVE ACTIVITY OF QUERCETIN DURING CARCINOGENESIS IN CERVIX UTERI IN MICE

Abstract no :  4-1..4-DG-087
Author(s) :  De, S.; Chakraborty, J.; Charaborty, R.N.; Das, S
Address :  (Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, Calcutta 700 026, WB, India)
Source :  PhytotherapyResearch, v. 14(5): p. 347-351, 2000
Title :  CHEMO PREVENTIVE ACTIVITY OF QUERCETIN DURING CARCINOGENESIS IN CERVIX UTERI IN MICE
Abstract :      The chemo preventive action of quercetin, a bioflavonoid, present in many plants, was examined during20-methyl cholanthrene induced cervical neoplasia in Swiss albino mice. The effects were evaluated on the basis of histopathological observation of the cervical epithelium, micronucleus frequency in vaginal exfoliated cells and some biochemical parameters in the host liver. Quercetin was found to arrest or reverse the progression of cervical neoplasia. The micronucleus frequency was reduced following its administration. The potential ant carcinogenic effect of quercetin has been attributed to its antioxidant property which was reflected in the lipid peroxides and their role in the host detoxification system, as expressed in liver glutathione level, glutathione-S-transferase, glutathioneperoxidase, catalase and super oxide dismutase activity. As an integral part of the diet quercetin has been suggested offer protection to the epithelium from the damaging effects of carcinogenic chemicals,

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