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Abstract no :  4-1..4-DG-086
Author(s) :  Datta, S.; Sinha, S.; Bhattacharyya, P
Address :  (Department of Chemistry, Bose Institute 93/1, A.P.C. Road, Calcutta 700 009, WB, India)
Source :  Journal of Ethnopharmacology, v. 67(3): p. 259-267, 1999
Title :  EFFECT OF A HERBAL PROTEIN, CI-I, ISOLATED FROM CAJANUS INDICUS ON IMMUNE RESPONSE OF CONTROL AND STRESSED MICE
Abstract :      The effect of an herbal protein, Cl-1, purified from the leaves of Cajanus indicus was evaluated as a probable immunomodulator on immune response in control and stressed mice. In mice, sensitized with sheep red blood cells(SRBC), Cl-1 enhanced lgG level by 28 percent over control(P less than 0.05). Primary and secondary antibody response to SRBC and bovine serum albumin (BSA) were significantly increased in CI-I treated group. Furthermore Cl-I facilitated the delayed type of hypersensitivity (DTH) response to SRBC in sensitized mice and also enhanced leucocytes and macrophage migration inhibition response in immunized mice. A fewer mice displayed symptoms of anaphylactic shock after Cl-I administration at a dose of 6.0mg/kg body wt. in BSA sensitized mice. The immediate effect of Cl-1 on anaphylactic shock was not seen when 150microg of Cl-1 was injected in combination with BSA in the shocking injection. The results suggested that CI-I influences both humoral and cell-mediated immune response.

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