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Abstract no :  2-1&2-DG-101
Author(s) :  Guevara, A.P.; Vargas, C.; Uy,M.
Address :  Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City, Philippines  Philippine
Source :  Journal of Science, v.125(3): p. 175-184, 1996.
Title :  ANTI-INFLAMMATORY AND ANTITUMOR ACTIVITIES OF SEED EXTRACTS OF MALUNGGAY, MORINGA OLEIFERA L. (MORINGACEAE).
Abstract :      The Seeds of malunggay, Moringa oleifera (SHIGRU), were extracted with distilled ethanol and concentrated under reduced pressure at 40 degree C.  The resulting extract was partitioned between hexane, ethylacetate,  butanol and water.  The solvent fractions were concentrated under reduced pressure.  The crude ethanol extract of dried seeds inhibited the carrageenan-induced inflammation in the hind paw of mice by 85 percent at a dosage of 3 mg/g body weight while the mature green seeds by 77 percent.  The hexane fraction of the crude ethanol extract also inhibited inflammation by 77 percent at the same dosage while both butanol and water fractions inhibited inflammation by only 34 percent.  These results indicate the strong antiinflammatory activities of the crude ethanol extract and the hexane fraction.  The ethylacetated fraction caused a 267 percent increase in inflammation and exhibited toxicity.  The mice died after oral administration of the fraction.  The crude ethanol extract also inhibited the formation of Epstein-Barr virus-early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate.  At a dosage of 100 microg/ml the extract inhibited EBV-EA formation by 100 percent suggesting its antitumour-promoting activity.

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