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PREVENTIVE EFFECT OF EUGENOL ON PAF AND ETHANOL-INDUCED GASTRIC MUCOSAL DAMAGE

Abstract no :  4-1..4-DG-081
Author(s) :  Capasso, R.; Pinto, L.; Vuotto, M.L.; DiCarlo, G
Address :  (Department of Experimental Pharmacology, University of Naples, 'Federico II', Via D.Montesanoo, 49, 80131 Naples, Italy)
Source :  Fitoterapia, v. 71(Suppl.): p. S131-S137, 2000
Title :  PREVENTIVE EFFECT OF EUGENOL ON PAF AND ETHANOL-INDUCED GASTRIC MUCOSAL DAMAGE
Abstract :      The antiulcerogenic activity of eugenol, a natural compound obtained from Myristica fragrans (JATIPHALA) has been discussed. Gastric ulcers, induced by administration of two ulcerogenic agents, i.e. platelet activating factor (PAF) and ethanol, were dose-dependently and significantly reduced by eugenol (10-100 mg/kg, p.o.)pretreatment. Eugenol was able to reduce not only the number of ulcers but also the gravity of lesions.

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