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NARDOSTACHYS JATAMANSI PROTECTS AGAINST LIVER DAMAGE INDUCED BY THIOACETAMIDE IN RATS

Abstract no :  4-1..4-DG-074
Author(s) :  Ali, S.; Ansari, K.A.; Jafry, M.A.; Kabeer, H.; Diwakar, G
Address :   (Department of Ilmul-Advia, Faculty of Medicine, Hamdard University, New Delhi 110 062, India)
Source :  Journal of Ethno pharmacology, v. 71(3): p. 359-363, 2000
Title :  NARDOSTACHYS JATAMANSI PROTECTS AGAINST LIVER DAMAGE INDUCED BY THIOACETAMIDE IN RATS
Abstract :      Pretreatment of ethanol extract of Nardostachys jatamansi (JATAMAMSI) rhizomes (800 mg/kg body wt, orally) for three consecutive days significantly ameliorated the liver damage in rats exposed to the hepatotoxic compound thioacetamide. Elevated levels of serum transaminases (aminotransferases) and alkaline phosphatase, observed in thioacetamide alone treated group of animals, were significantly lowered in N. jatamansi pretreated rats. Pretreatment of the animals with the extract also resulted in an increase in survival of rats intoxicated with LD90 dose of the hepatotoxic drug.

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