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GUAVA LEAF EXTRACT AND TOPICAL HAEMOSTASIS

Abstract no :  4-1..4-DG-095
Author(s) :  Jairaj, P.; Ongkrajang.Y.; Thongpraditchote, S.; Peungvicha, P.; Bunyapraphatsara, N.; Opartkiattikul, N
Address :  (Department of Physiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand)
Source :   Phytotherapy Research, v. 14(5): p.388-391, 2000
Title :  GUAVA LEAF EXTRACT AND TOPICAL HAEMOSTASIS
Abstract :      The effects of guava Psidium guajava (PERUKA) leaf extract on the bleeding time and three main mechanisms of haemostasis: vasoconstriction, platelet aggregation and blood coagulation, were investigated. The water extract of guava leaves did not shorten bleeding times in rats. Guava leaf extract potentiated the vascular muscle contraction induced in rabbits by phenylephrine, and when given alone it stimulated human platelet aggregation in vitro in a dose-dependent manner. On the other hand, it significantly prolonged blood coagulation; activated partial thromboplastin time (APTT) test (p less than 0.05). The higher the concentration of the extract, the longer APTT was ob-served. Water extract of guava leaves showed ambiguous effects on the haemostatic system. Guava leaf extract did not affect bleeding times, it stimulated vasoconstriction and platelet aggregation but it inhibited blood coagulation. Guava leaf extract has not been recommended as a haemostatic agent.

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