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ANTITUSSIVE EFFECT OF ADHATODA VASICA EXTRACT ON MECHANICAL OR CHEMICAL STIMULATION-INDUCED COUGHING IN ANIMALS

Abstract no :  4-1..4-DG-088
Author(s) :  Dhuley, J.N
Address :  (Department of Pharmacology and Toxicology, Research Division, Hindustan Antibiotics Ltd., Pimpri, Pune 411 018, Maharashtra, India)
Source :  Journal of Ethnopharmacology, v. 67(3): p. 361-365, 1999
Title :  ANTITUSSIVE EFFECT OF ADHATODA VASICA EXTRACT ON MECHANICAL OR CHEMICAL STIMULATION-INDUCED COUGHING IN ANIMALS
Abstract :      The antitussive activity of Adhatoda vasica (VASA) (AV) extract was evaluated in anaesthetized guinea pigs and -rabbits and in un-anaesthetized guinea pigs. AV was shown to have a good antitussive activity. Intravenously, it was 1/20-1/40 as active as codeine on mechanically and electrically induced coughing in rabbits and guinea-pigs. After oral administration to the guinea-pig the antitussive activity of AV was similar to codeine against coughing induced by irritant aerosols.

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