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ANTITUMOUR ACTIVITY OF THE AQUEOUS-ALCOHOLIC EXTRACTS FROM UNRIPE COTTON. AN EXPOSURE OF MURINE B16 MELANOMA AND L1210LYMPHOMA CELLS TO THE AQUEOUS-ALCOHOLIC EXTRACTS FROM UN-RIPE COTTON BALLS OF GOSSYPIUM INDICUM RESULTED IN THEIR SEVERE DEATHS IN TIME- AND CONCENTRATION-DEPENDENT MANNERS. OF THE EXTRACTS, HYDROPHILIC FRACTIONS WERE MOST EFFICACIOUS FOR THE ANTITUMOUR ACTIVITY AND FOUND TO CONTAIN CERTAIN BALL OF GOSSYPIUM INDICUM

Abstract no :  4-1..4-DG-085
Author(s) :  Choi, J.J.; Yoon, K.N.; Lee, S.K.; Lee, Y.H.; Park, J.H.; Kirn, W.Y.; Kirn, J.K.; Kirn, W.K
Address :  (Department of Pharmacology, College of Medicine, Division of Neuroscience. Medical Research Center, Ewha Woman University, Seoul 158-056, Korea)
Source :   Archives of Pharmacal Research, v.21 (3): p. 266-272, 1998
Title :  ANTITUMOUR ACTIVITY OF THE AQUEOUS-ALCOHOLIC EXTRACTS FROM UNRIPE COTTON. AN EXPOSURE OF MURINE B16 MELANOMA AND L1210LYMPHOMA CELLS TO THE AQUEOUS-ALCOHOLIC EXTRACTS FROM UN-RIPE COTTON BALLS OF GOSSYPIUM INDICUM RESULTED IN THEIR SEVERE DEATHS IN TIME- AND CONCENTRATION-DEPENDENT MANNERS. OF THE EXTRACTS, HYDROPHILIC FRACTIONS WERE MOST EFFICACIOUS FOR THE ANTITUMOUR ACTIVITY AND FOUND TO CONTAIN CERTAIN BALL OF GOSSYPIUM INDICUM
Abstract :      amounts of catechin and its derivatives. The hydrophillic extract fraction had approximately 10 times more cytotoxic effects on B12 and L1210 cells than on isolated urine thymocytes. High concentrations (greater than 150microg/ml) mainly induced necrotic cell death. At low concentrations (less than 100 microg/ml), not only necrosis but also apoptosis of the two tumor cell lines was induced. Certain ingredients of the cotton ball extract of G. indicum have been reported to show antitumour activity.

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